Efficacy of structurally diverse aldose reductase inhibitors on experimental periodontitis in rats.

Background: To study aldose reductase and the sorbitol pathway in periodontitis and diabetes, rats with experimental periodontitis with or without diabetes were treated with three structurally diverse aldose reductase inhibitors (ARIs).

Methods: Periodontitis was induced with three consecutive palatal injections of Porphyromonas gingivalis lipopolysaccharide (LPS) at 48-hour intervals between the first and second molars on the right side in young, age-matched, streptozotocin-induced rats with and without diabetes 44 days after initiation of diets with and without the ARIs tolrestat, imirestat, and quercetin. As an internal control, phosphate-buffered saline (PBS) was similarly injected on the left side.

An accelerated in vitro model for adhesive testing.

Purpose: To develop a pilot in vitro accelerated laboratory testing protocol for assessing marginal sealing capability of dental adhesives.

Methods: Occlusal cavities were prepared in 20 human molar teeth and restored with Spectrum TPH resin composite. Prime & Bond NT and Prompt L-Pop served as the adhesive for eight teeth each.