Publications by authors named "James D H Ong"
Article Synopsis
- The study focuses on understanding how pathogen genomics, specifically whole genome sequencing, is utilized in public health for infectious disease management in Australia and New Zealand.
- Researchers plan to use qualitative comparative analysis (QCA) to compare cases of pathogen genomics application and develop a rubric to pinpoint influential factors affecting its use.
- The results will be drawn from a combination of document reviews and interviews with health technicians, aiming to uncover pathways that enhance the effectiveness of pathogen genomics in public health responses.
The severity of influenza A virus (IAV) infection can range from asymptotic to mild to severe. Infections, such as those seen following outbreaks of avian IAV, are associated with hyperinflammatory responses and the development of fatal disease. There is a continual threat that a novel or pandemic IAV will circulate in humans with high rates of mortality.
View Article and Find Full Text PDFThe inflammasome NLRP3 is activated by pathogen associated molecular patterns (PAMPs) during infection, including RNA and proteins from influenza A virus (IAV). However, chronic activation by danger associated molecular patterns (DAMPs) can be deleterious to the host. We show that blocking NLRP3 activation can be either protective or detrimental at different stages of lethal influenza A virus (IAV).
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