Publications by authors named "James Cory-Wright"
Article Synopsis
- The L-arginine biosynthesis pathway has 8 enzymes that help turn a substance called L-glutamate into another good one called L-arginine.
- Certain types of bacteria that can't make L-arginine can be easily killed in mice, and stopping an enzyme called ArgJ helps get rid of a long-lasting infection.
- Researchers are looking at four of these enzymes to find new medicine to fight tuberculosis and have already found some promising candidates through various tests.
Article Synopsis
- Coenzyme A (CoA) is essential for life and plays a key role in metabolic processes, making its biosynthesis an attractive drug target, especially for treating Mycobacterium tuberculosis.
- The enzyme CoaBC, a bifunctional protein, is crucial for CoA production and its depletion is lethal to M. tuberculosis.
- Researchers have characterized the structure of CoaBC from Mycobacterium smegmatis and discovered new inhibitors that target a unique site on the CoaB enzyme, potentially leading to effective treatments for tuberculosis.
Surgical Management of Esophageal Achalasia in Pediatrics: A Systematic Review.
Eur J Pediatr Surg
February 2020
Introduction: There are no evidence-based guidelines on the surgical management of esophageal achalasia (OA) in children. This can be a challenging condition with significant physical and psychological morbidity. Our aim was to identify the most common management modalities and their outcomes.
View Article and Find Full Text PDFGABAρ receptors are a subfamily of the GABA receptor family of pentameric ligand-gated ion channels (pLGICs). Each of the five subunits has four transmembrane α-helices (M1-M4), with M4 most distant from the central pore. Aromatic residues in this M4 helix are important for receptor assembly in pLGICs and also may interact with adjacent lipids and/or residues in neighboring α-helices and the extracellular domain to modify or enable channel gating.
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