Bounding the generation time distribution uncertainty on estimation from exponential growth rates.

The basic reproduction number is one of the main parameters determining the spreading of an epidemic in a population of susceptible individuals. Wallinga and Lipsitch proposed a method for estimating using the Euler-Lotka equation, which requires the Laplace transform of the generation interval distribution. The determination of the generation time distribution is challenging, as the generation time is not directly observable.

Constitutive model for the rheology of biological tissue.

The rheology of biological tissue is key to processes such as embryo development, wound healing, and cancer metastasis. Vertex models of confluent tissue monolayers have uncovered a spontaneous liquid-solid transition tuned by cell shape; and a shear-induced solidification transition of an initially liquidlike tissue. Alongside this jamming/unjamming behavior, biological tissue also displays an inherent viscoelasticity, with a slow time and rate-dependent mechanics.

The Use of Oxygen/Air Blender during Transoral Laser Microsurgery with Supraglottic Manual Jet Ventilation: A Safe Approach.

Background: Surgical fires are known, preventable, and devastating complications of transoral microlaryngeal laser surgery. Several guidelines have recommended maintaining the fraction of inspired oxygen concentration (FiO) at or below 30% for open delivery cases. We hereby present our experience utilizing an air/oxygen gas mixing device (blender) attached to a supraglottic manual jet ventilator during transoral laser microlaryngeal surgery in three cases to control oxygen levels.

Traumatic Injuries of the Parotid Gland and Duct.

This review will focus on the key steps in the recognition of parotid gland and duct injuries focusing on the important steps needed at the initial assessment. Management planning is presented in the way that trauma surgeons interact with patients, highlighting the important parts of the informed consent conversation followed by the key information that must be communicated to the anesthesia and operating room teams, which ensures proper monitoring and equipment needs are in place. Short-term and long-term outcomes for patients with persistent sequelae of the trauma and their management are reviewed.

Shear-Driven Solidification and Nonlinear Elasticity in Epithelial Tissues.

Biological processes, from morphogenesis to tumor invasion, spontaneously generate shear stresses inside living tissue. The mechanisms that govern the transmission of mechanical forces in epithelia and the collective response of the tissue to bulk shear deformations remain, however, poorly understood. Using a minimal cell-based computational model, we investigate the constitutive relation of confluent tissues under simple shear deformation.

Geographical distribution of the health crisis of war in the Tigray region of Ethiopia.

War destroys health facilities and displaces health workers. It has a devastating impact on population health, especially in vulnerable populations. We assess the geographical distribution of the impact of war on healthcare delivery by comparing the pre-November 2020 and the November to June 2021 status of health facilities in the Tigray region of Ethiopia.

Tonsil Riots and Vaccine Hesitancy: A 100-Year Legacy of Medical Mistrust.

The "tonsil riots" of 1906 were panics that developed at several public schools in historically immigrant-dominated neighborhoods of New York City (NYC). Per archived newspaper articles, several NYC public schools asked for parental consent to have Board of Health physicians come and perform tonsillectomy and adenoidectomy on their students. When children subsequently returned home from school "drooling mouthfuls of blood and barely able to speak," mothers reacted with panic and flocked to the schools demanding the safe return of their children.

Aquablation, Prostatic Urethral Lift, and Transurethral Water Vapor Therapy: A Comparison of Device-Related Adverse Events in a National Registry.

Aquablation, prostatic urethral lift (PUL), and transurethral water vapor therapy (TWVT) have demonstrated efficacy for the treatment of benign prostatic hyperplasia (BPH). Our objective was to describe device malfunctions and complications to help guide procedural selection and performance. The Manufacturer and User Facility Device Experience (MAUDE) database was examined for reports related to the use of these three procedures for the treatment of BPH between January 1, 2015, and July 1, 2020.

Modelling temperature extremes in the Limpopo province: bivariate time-varying threshold excess approach.

A common problem that arises in extreme value theory when dealing with several variables (such as weather or meteorological) is to find an appropriate method to assess their joint or conditional multivariate extremal dependence behaviour. The method for choosing an appropriate threshold in peaks-over threshold approach is also another problem of endless debate. In this era of climate change and global warming, extreme temperatures accompanied by heat waves and cold waves pose serious economic and health challenges particularly in small economies or developing countries like South Africa.

Ductile and Brittle Yielding in Thermal and Athermal Amorphous Materials.

We study theoretically the yielding of sheared amorphous materials as a function of increasing levels of initial sample annealing prior to shear, in three widely used constitutive models and three widely studied annealing protocols. In thermal systems we find a gradual progression, with increasing annealing, from smoothly "ductile" yielding, in which the sample remains homogeneous, to abruptly "brittle" yielding, in which it becomes strongly shear banded. This progression arises from an increase with annealing in the size of an overshoot in the underlying stress-strain curve for homogeneous shear, which causes a shear banding instability that becomes more severe with increasing annealing.

Why we need more coronavirus tests than we think we need.

on the importance of testing a random sample.

Modelling non-stationary annual maximum flood heights in the lower Limpopo River basin of Mozambique.

In this article we fit a time-dependent generalised extreme value (GEV) distribution to annual maximum flood heights at three sites: Chokwe, Sicacate and Combomune in the lower Limpopo River basin of Mozambique. A GEV distribution is fitted to six annual maximum time series models at each site, namely: annual daily maximum (AM1), annual 2-day maximum (AM2), annual 5-day maximum (AM5), annual 7-day maximum (AM7), annual 10-day maximum (AM10) and annual 30-day maximum (AM30). Non-stationary time-dependent GEV models with a linear trend in location and scale parameters are considered in this study.

Abbot Ice Shelf, structure of the Amundsen Sea continental margin and the southern boundary of the Bellingshausen Plate seaward of West Antarctica.

Unlabelled: Inversion of NASA Operation IceBridge airborne gravity over the Abbot Ice Shelf in West Antarctica for subice bathymetry defines an extensional terrain made up of east-west trending rift basins formed during the early stages of Antarctica/Zealandia rifting. Extension is minor, as rifting jumped north of Thurston Island early in the rifting process. The Amundsen Sea Embayment continental shelf west of the rifted terrain is underlain by a deeper, more extensive sedimentary basin also formed during rifting between Antarctica and Zealandia.

Safety and efficacy of a patient-controlled bladder management system for treating urinary retention in men.

Aims: The CymActive™ Bladder Management System (BMS) is a self-retaining, intraurethral catheter with a patient-controlled magnetic valve that allows cyclical bladder filling and emptying, without external appliances. We determined the safety and efficacy of the BMS in men with urinary retention who required catheterization for more than 7 days.

Methods: Men requiring continuous drainage, bladder capacity less than 300 ml, history of prostatic or urethral surgery, or urethral length outside of defined limits, were excluded.

A multi-institutional prospective trial in the USA confirms that the 4Kscore accurately identifies men with high-grade prostate cancer.

Background: The 4Kscore combines measurement of four kallikreins in blood with clinical information as a measure of the probability of significant (Gleason ≥7) prostate cancer (PCa) before prostate biopsy.

Objective: To perform the first prospective evaluation of the 4Kscore in predicting Gleason ≥7 PCa in the USA.

Design, Setting, And Participants: Prospective enrollment of 1012 men scheduled for prostate biopsy, regardless of prostate-specific antigen level or clinical findings, was conducted at 26 US urology centers between October 2013 and April 2014.

Copper complexation screen reveals compounds with potent antibiotic properties against methicillin-resistant Staphylococcus aureus.

Macrophages take advantage of the antibacterial properties of copper ions in the killing of bacterial intruders. However, despite the importance of copper for innate immune functions, coordinated efforts to exploit copper ions for therapeutic interventions against bacterial infections are not yet in place. Here we report a novel high-throughput screening platform specifically developed for the discovery and characterization of compounds with copper-dependent antibacterial properties toward methicillin-resistant Staphylococcus aureus (MRSA).