Publications by authors named "James Ch Hardwick"
Article Synopsis
- Human colorectal cancer-derived cancer-associated fibroblasts (CAFs) can cross-present neoantigens, which enhances their ability to interact with tumor-specific CD8+ T cells compared to normal fibroblasts.
- The study utilized advanced genetic techniques and assays to identify the molecular mechanisms involved, particularly highlighting the role of the lysosomal protease cathepsin S.
- Results showed that interaction between CAFs and CD8+ T cells can lead to reduced T cell activation and increased exhaustion, suggesting that CAFs may negatively impact tumor immunity.
Tumour-stroma ratio has poor prognostic value in non-pedunculated T1 colorectal cancer: A multi-centre case-cohort study.
United European Gastroenterol J
November 2020
Background: Current risk stratification models for early invasive (T1) colorectal cancer are not able to discriminate accurately between prognostic favourable and unfavourable tumours, resulting in over-treatment of a large (>80%) proportion of T1 colorectal cancer patients. The tumour-stroma ratio (TSR), which is a measure for the relative amount of desmoplastic tumour stroma, is reported to be a strong independent prognostic factor in advanced-stage colorectal cancer, with a high stromal content being associated with worse prognosis and survival. We aimed to investigate whether the TSR predicts clinical outcome in patients with non-pedunculated T1 colorectal cancer.
View Article and Find Full Text PDFBackground: Screening of patients with familial adenomatous polyposis (FAP) have led to a substantial reduction in mortality due to colorectal cancer (CRC). Recent guidelines suggest that surveillance of non-intestinal malignancies should also be considered in those patients. However, the value of these surveillance programmes is unknown.
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