Delay-driven oscillations via Axin2 feedback in the Wnt/β-catenin signalling pathway.

The Wnt signalling pathway plays an important role in development, disease, and normal tissue function. Mathematical models for Wnt signalling have predominantly focused on quantitatively predicting changes in steady-state β-catenin concentrations (the main downstream protein regulated by canonical Wnt signalling). One of the genes targeted for expression by Wnt/β-catenin signalling is the negative Wnt regulator Axin2.