Publications by authors named "James Barter"
Article Synopsis
- The study aimed to assess the safety and tolerability of an individualized starting dose (ISD) of niraparib in patients with newly diagnosed advanced ovarian cancer who responded to platinum-based chemotherapy.
- An analysis of treatment-emergent adverse events (TEAEs) revealed that common side effects occurred early, with hematologic TEAEs resolving in over 89% of patients within a median duration of about 2 weeks.
- Overall, the niraparib ISD was found to be well tolerated, indicating the importance of close monitoring after starting treatment and helping set patient expectations regarding safety.
Background: Treatment options for patients with platinum-resistant/refractory ovarian cancers are limited and only marginally effective. The development of novel, more effective therapies addresses a critical unmet medical need. Olvimulogene nanivacirepvec (Olvi-Vec), with its strong immune modulating effect on the tumor microenvironment, may provide re-sensitization to platinum and clinically reverse platinum resistance or refractoriness in platinum-resistant/refractory ovarian cancer.
View Article and Find Full Text PDFObjective: The purpose of this multicenter, open label, randomized phase III study was to determine whether ixabepilone resulted in improved overall survival (OS) compared with commonly used single-agent chemotherapy (doxorubicin or paclitaxel) in women with locally advanced, recurrent, or metastatic endometrial cancer with at least one failed prior platinum-based chemotherapeutic regimen.
Methods: Patients were randomized 1:1 to ixabepilone (40mg/m(2)), or either paclitaxel (175mg/m(2)) or doxorubicin (60mg/m(2)), every 21days. Patients that had previously received an anthracycline were randomized to ixabepilone or paclitaxel; all other patients were randomized to ixabepilone or doxorubicin.
Background And Objectives: To evaluate the operative outcomes between robotic, laparoscopic, and abdominal myomectomies performed by a private gynecologic oncology practice in a suburban community hospital.
Methods: The medical records of 322 consecutive robotic, laparoscopic, and abdominal myomectomies performed from January 2007 through December 2009 were reviewed. The outcomes were collected from a retrospective review of patient medical records.
Purpose: To examine early changes in CA125 relative to objective response in patients with recurrent ovarian cancer treated with pegylated liposomal doxorubicin (PLD) or topotecan and to compare the CA125 trends between the two chemotherapeutics.
Patients And Methods: Patients with recurrent ovarian cancer, all of whom had measurable or evaluable disease, were randomized to receive 50 mg/m2 PLD every 28 days (n = 239) or 1.5 mg/m2 topotecan for 5 days every 21 days (n = 235) as part of a previously reported multicenter study.
Article Synopsis
- The study aimed to compare the handling and 6-month clinical outcomes of a long-term absorbable suture (PLG) versus a permanent monofilament suture (polypropylene) for fascial closure in high-risk patients.
- 203 patients were enrolled, and while demographics were similar, PLG exhibited better handling characteristics, such as smoother knot tie-down and strength, although the monofilament was easier for tissue passage.
- No significant differences were noted in post-surgical complications or pain, suggesting that PLG is a viable non-permanent option for patients with high risk for poor wound outcomes.
A fully polarimetric optical camera system has been constructed to obtain polarimetric information simultaneously from four synchronized charge-coupled device imagers at video frame rates of 60 Hz and a resolution of 640 x 480 pixels. The imagers view the same scene along the same optical axis by means of a four-way beam-splitting prism similar to ones used for multiple-imager, common-aperture color TV cameras. Appropriate polarizing filters in front of each imager provide the polarimetric information.
View Article and Find Full Text PDFUnlabelled: High-resolution transvaginal ultrasound frequently reveals incidental, simple ovarian cysts in asymptomatic postmenopausal women. Traditionally oophorectomy has been recommended for these women. However, evidence is emerging that most postmenopausal simple ovarian cysts are benign, allowing conservative management.
View Article and Find Full Text PDFContext: Despite quality assurance standards, Papanicolaou (Pap) test characteristics remain less than optimal.
Objective: To compare the societal costs and benefits of human papillomavirus (HPV) testing, Pap testing, and their combination to screen for cervical cancer.
Design, Setting, And Population: A simulation model of neoplasia natural history was used to estimate the societal costs and quality-adjusted life expectancy associated with 18 different general population screening strategies: Pap plus HPV testing, Pap testing alone, and HPV testing alone every 2 or 3 years among hypothetical longitudinal cohorts of US women beginning at age 20 years and continuing to 65 years, 75 years, or death.