Publications by authors named "James Badenoch"
Neuroanatomical and prognostic associations of depression in Parkinson's disease.
J Neurol Neurosurg Psychiatry
September 2024
Article Synopsis
- Depression is common in individuals with Parkinson's disease (PD), with a prevalence that significantly increases from 10 years prior to diagnosis to 10 years after diagnosis.
- The study analyzed data from over 434,000 participants, revealing that depression is associated with a higher risk of developing PD and is linked to structural changes in the brain, particularly in areas like the thalamus and amygdala.
- Early depression in PD patients is a strong predictor of worse outcomes, such as higher chances of developing dementia and increased mortality risk, highlighting the need for better clinical evaluation and management of mental health in this population.
Background And Purpose: This review aims to characterize the pattern of post-COVID-19 cognitive impairment, allowing better prediction of impact on daily function to inform clinical management and rehabilitation.
Methods: A systematic review and meta-analysis of neurocognitive sequelae following COVID-19 was conducted, following PRISMA-S guidelines. Studies were included if they reported domain-specific cognitive assessment in patients with COVID-19 at >4 weeks post-infection.
Article Synopsis
- This study looked at how mental health issues like depression and anxiety affect people with Parkinson's disease and how these issues relate to their overall health and well-being.
- Researchers examined many studies to find out if having these mental health problems makes Parkinson's symptoms worse, which can include things like memory problems and falling.
- They found a lot of evidence showing that problems like psychosis are linked to worse outcomes in Parkinson's patients, indicating that mental health is really important for their overall condition.
Background: Neuropsychiatric presentations of monkeypox (MPX) infection have not been well characterised, despite evidence of nervous system involvement associated with the related smallpox infection.
Methods: In this pre-registered (PROSPERO ID 336649) systematic review and meta-analysis, we searched MEDLINE, EMBASE, PsycINFO, AMED and the preprint server MedRxiv up to 31/05/2022. Any study design of humans infected with MPX that reported a neurological or psychiatric presentation was included.
Article Synopsis
- A systematic review and meta-analysis was conducted to determine the prevalence of neuropsychiatric symptoms in COVID-19 survivors, examining 51 studies and over 18,000 patients.
- The most common symptoms identified were sleep disturbances (27.4%), fatigue (24.4%), cognitive impairment (20.2%), anxiety (19.1%), and post-traumatic stress (15.7%).
- Despite high study heterogeneity, findings suggest that neuropsychiatric symptoms are prevalent and persistent after COVID-19, with limited differences based on hospitalization or severity of illness.
There is accumulating evidence of the neurological and neuropsychiatric features of infection with SARS-CoV-2. In this systematic review and meta-analysis, we aimed to describe the characteristics of the early literature and estimate point prevalences for neurological and neuropsychiatric manifestations.We searched MEDLINE, Embase, PsycINFO and CINAHL up to 18 July 2020 for randomised controlled trials, cohort studies, case-control studies, cross-sectional studies and case series.
View Article and Find Full Text PDFBackground: Neuropathic pain negatively affects quality of life among people living with HIV (PLWH). This study examined the feasibility of conducting a full-scale randomized-controlled trial of online acceptance and commitment therapy ("ACT OPEN") for neuropathic pain in PLWH.
Methods: Using a parallel-groups design, thirty-eight participants were randomized to ACT OPEN or a waitlist control (2:1).
Objectives: Chronic neuropathic pain is common in people living with HIV. Psychological treatments can improve quality of life for people with chronic pain in general, and online delivery can increase access to these treatments. However, the acceptability of psychological treatment and online delivery have not been investigated in-depth in people living with HIV and chronic neuropathic pain.
View Article and Find Full Text PDFBackground: Movement disorders have been described in the context of different types of encephalitis. Among hyperkinetic manifestations, tics have sporadically been reported in cases of encephalitis resulting from a range of aetiologies.
Objective: This review aimed to assess the prevalence and characteristics of tics in patients with encephalitis.
Tourette syndrome (TS) is a neurodevelopmental condition characterized by multiple tics. Sensory symptoms play a key role in the clinical phenomenology and pathophysiology of TS, as most patients report premonitory urges driving tic expression. Interestingly, sensory symptoms have also been reported in other conditions characterized by repeated behaviors.
View Article and Find Full Text PDFBackground: Tourette syndrome (TS) and persistent motor/vocal tic disorders are neurodevelopmental conditions characterised by the chronic presence of motor and/or vocal tics. Patients with TS often present with co-morbid disorders, especially attention-deficit and hyperactivity disorder (which tends to improve after childhood), and obsessive-compulsive disorder (which can persist in adulthood). We set out to explore pharmacotherapy for tics in adult patients with TS and persistent motor/vocal tic disorders, as well as its relationship with the presence of co-morbid conditions.
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