Publications by authors named "James Anthony McCaul"
Article Synopsis
- The study evaluates the effects of PI3Kδ inhibitor AMG319 in patients with head and neck cancer, showing that it reduces regulatory T cells while boosting the activity of tumor-fighting T cells.
- However, the treatment resulted in significant immune-related adverse events (irAEs) in nearly half of the patients, raising concerns about systemic effects on T cells.
- Mouse models suggest that altering dosing regimens could reduce these toxic effects while still effectively shrinking tumors, prompting further exploration of treatment strategies.
Pharmacologic modalities in the treatment of osteoradionecrosis of the jaw.
Oral Maxillofac Surg Clin North Am
May 2014
Managing osteoradionecrosis (ORN) of the facial bones is a challenge in maxillofacial head and neck surgery. Changes in understanding of ORN of the jaws has led to new studies using novel therapeutic modalities to manage this disorder. These treatment regimens may allow medical management to replace major reconstructive surgery for some patients who have already undergone chemoradiotherapy or combined modality therapy for head and neck cancer.
View Article and Find Full Text PDFIntroduction: Craniomaxillofacial surgeons require to estimate the orbital volume in a variety of clinical situations. This paper evaluates a new method based on software analysis of computerized tomography (CT) scan data.
Material And Methods: Five dried skulls with prosthetic globes and periorbita were non-helically scanned in an Elscint 2400 CT scanner.