Electrochemical oxidation of pharmaceuticals in synthetic fresh human urine: Using selective radical quenchers to reveal the dominant degradation pathways and the scavenging effects of individual urine constituents.

Electrochemical oxidation of fresh human urine is a promising method to prevent pharmaceuticals from being discharged into the environment. Here, we evaluate the importance of electro-generated oxidants and direct anodic oxidation for degradation of four pharmaceutical (cyclophosphamide (CP), carbamazepine (CBZ), sulfamethoxazole (SMX) and ibuprofen (IBP)) accounting for the scavenging effect of urine constituents using boron-doped diamond (BDD) and IrO electrodes. Allyl alcohol and tert-butanol were used as selective quenchers for adsorbed and dissolved radicals, respectively.

Fracture of dual lumen cannula leading to cerebrovascular accident in a patient supported with ECMO.

Extended duration extracorporeal membrane oxygenation (ECMO), using dual-lumen cannulas, is being used with increased frequency to support patients, including those with COVID-19; both as a bridge to transplant and lung recovery. During such an extended duration of support, there are several factors that might lead to the attrition of the physical structure of the ECMO cannulas, predisposing them to the risk of fracture. Although rare, fracture of the ECMO cannula can be a potentially lethal event.

Selective oxidation of pharmaceuticals and suppression of perchlorate formation during electrolysis of fresh human urine.

Urine comprises only a small (~1%) volumetric fraction of municipal wastewater, but represents a dominant source of pharmaceuticals, many of which may pass through conventional wastewater treatment and pose risks to aquatic ecosystems. Point-source treatment of source-separated urine presents a unique opportunity to degrade pharmaceuticals before dilution with wastewater, and electrochemical advanced oxidation processes are one increasingly investigated option. However, they often lead to the formation of oxidation byproducts including chlorate, perchlorate at very high concentrations.

Inference of the Neutron Star Equation of State from Cosmological Distances.

Finite-size effects on the gravitational wave signal from a neutron star merger typically manifest at high frequencies where detector sensitivity decreases. Proposed sensitivity improvements can give us access both to stronger signals and to a myriad of weak signals from cosmological distances. The latter will outnumber the former and the relevant part of the signal will be redshifted towards the detector's most sensitive band.

Equation of State Constraints from the Threshold Binary Mass for Prompt Collapse of Neutron Star Mergers.

Using hydrodynamical simulations for a large set of high-density matter equations of state (EOSs), we systematically determine the threshold mass M_{thres} for prompt black-hole formation in equal-mass and asymmetric neutron star (NS) mergers. We devise the so far most direct, general, and accurate method to determine the unknown maximum mass of nonrotating NSs from merger observations revealing M_{thres}. Considering hybrid EOSs with hadron-quark phase transition, we identify a new, observable signature of quark matter in NS mergers.

Measuring Spin of the Remnant Black Hole from Maximum Amplitude.

Gravitational waves emitted during the merger of two black holes carry information about the remnant black hole, namely its mass and spin. This information is typically found from the ringdown radiation as the black hole settles to a final state. We find that the remnant black hole spin is already known at the peak amplitude of the gravitational wave strain.

Identifying a First-Order Phase Transition in Neutron-Star Mergers through Gravitational Waves.

We identify an observable imprint of a first-order hadron-quark phase transition at supranuclear densities on the gravitational-wave (GW) emission of neutron-star mergers. Specifically, we show that the dominant postmerger GW frequency f_{peak} may exhibit a significant deviation from an empirical relation between f_{peak} and the tidal deformability if a strong first-order phase transition leads to the formation of a gravitationally stable extended quark matter core in the postmerger remnant. A comparison of the GW signatures from a large, representative sample of microphysical, purely hadronic equations of state indicates that this imprint is only observed in those systems which undergo a strong first-order phase transition.

Complexation Chemistry in N,N-Dimethylformamide-Based Molecular Inks for Chalcogenide Semiconductors and Photovoltaic Devices.

Molecular inks based on dimethyl sulfoxide, thiourea (TU), and metal salts have been used to form high optoelectronic quality semiconductors and have led to high power conversion efficiencies for solution-processed photovoltaic devices for CuZnSn(S,Se) (CZTS), CuZn(Ge,Sn)(S,Se) (CZGTS), CuIn(S,Se) (CIS), and Cu(In,Ga)(S,Se) (CIGS). However, several metal species of interest, including Ag(I), In(III), Ge(II), and Ge(IV), either have low solubility (requiring dilute inks) or lead to precipitation or gelation. Here, we demonstrate that the combination of N,N-dimethylformamide (DMF) and TU has the remarkable ability to form intermediate-stability acid-base complexes with a wide number of metal chloride Lewis acids (CuCl, AgCl, ZnCl, InCl, GaCl, SnCl, GeCl, and SeCl), to give high-concentration stable molecular inks.

Tracking Black Hole Kicks from Gravitational-Wave Observations.

Coalescing binary black holes emit anisotropic gravitational radiation. This causes a net emission of linear momentum that produces a gradual acceleration of the source. As a result, the final remnant black hole acquires a characteristic velocity known as recoil velocity or gravitational kick.

Cardiac physiologic and genetic predictors of hyperoxia-induced acute lung injury in mice.

Exposure of mice to hyperoxia produces pulmonary toxicity similar to acute lung injury/acute respiratory distress syndrome, but little is known about the interactions within the cardiopulmonary system. This study was designed to characterize the cardiopulmonary response to hyperoxia, and to identify candidate susceptibility genes in mice. Electrocardiogram and ventilatory data were recorded continuously from 4 inbred and 29 recombinant inbred strains during 96 hours of hyperoxia (100% oxygen).

Effects of buprenorphine, meloxicam, and flunixin meglumine as postoperative analgesia in mice.

C57BL/6NCrl male mice (n = 60; age, 6 to 7 wk) underwent partial hepatectomy or no surgery and were given 1 of 3 analgesics pre- and postoperatively. Food and water consumption, body weight, running wheel activity, locomotor activity, and serum corticosterone concentrations were measured before and after surgery. Mice that were surgically manipulated weighed significantly less on days 1 through 3 after surgery than did mice not manipulated surgically.

Impact of ABCB1 allelic variants on QTc interval prolongation.

Purpose: Although the ABCB1 (P-glycoprotein) drug transporter is a constituent of several blood-tissue barriers (i.e., blood-brain and blood-nerve), its participation in a putative blood-heart barrier has been poorly explored.

Defective generation of a humoral immune response is associated with a reduced incidence and severity of collagen-induced arthritis in microsomal prostaglandin E synthase-1 null mice.

Microsomal PGE synthase-1 (mPGES-1) is an inducible enzyme that acts downstream of cyclooxygenase and specifically catalyzes the conversion of PGH(2) to PGE(2). The present study demonstrates the effect of genetic deletion of mPGES-1 on the developing immunologic responses and its impact on the clinical model of bovine collagen-induced arthritis. mPGES-1 null and heterozygous mice exhibited decreased incidence and severity of arthritis compared with wild-type mice in a gene dose-dependent manner.

The genetic contribution to heart rate and heart rate variability in quiescent mice.

Recent studies have suggested a genetic component to heart rate (HR) and HR variability (HRV). However, a systematic examination of the genetic contribution to the variation in HR and HRV has not been performed. This study investigated the genetic contribution to HR and HRV using a wide range of inbred and recombinant inbred (RI) mouse strains.

Identification of Xenopus heat shock transcription factor-2: conserved role of sumoylation in regulating deoxyribonucleic acid-binding activity of heat shock transcription factor-2 proteins.

Heat shock transcription factor (Hsf)-1 and Hsf2 are members of the heat shock factor (HSF) protein family involved in heat shock protein (hsp) gene regulation, a regulation that is critical for the ability of cells to survive exposure to stress conditions. Although the role of Hsf1 in binding and activating transcription of hsp gene promoters in response to cell stress is well established, how Hsf2 enhances stress-induced hsp expression is not understood. To gain an insight into the critical conserved features of the regulation and function of Hsf2, we have identified and characterized the Hsf2 protein from Xenopus laevis.

Gill trematodes (flukes) in wild-caught killifish (Fundulus heteroclitus).

Three wild caught killifish (Fundulus heteroclitus) on an Institutional Animal Care and Use Committee-approved protocol were found dead within 2 days after being received. The fish were housed in two separate aquaria. Aquarium water was evaluated, and pH, salinity, ammonia, nitrate, and nitrite levels were within acceptable parameters.

Mammary gland development in adult mice requires epithelial and stromal estrogen receptor alpha.

Complete mammary gland development takes place following puberty and depends on the estrogen receptor (ER)alpha and the progesterone receptor (PR) and is tightly regulated by the interaction of the mammary epithelium with the stromal compartment. Studies using mammary tissues of immature mice have indicated that stromal but not epithelial ER alpha is required for mammary gland growth. This study investigates whether these same tissue growth requirements of neonate tissue are necessary for mammary development and response in adult mice.