Clinical inquiries. What does the evidence tell us about treating very-high-risk patients to an LDL <70 mg/dL?

No studies directly compare low-density lipoprotein (LDL) levels <70 mg/dL to levels of 71 to 100 mg/dL in very-high-risk patients. However, no evidence suggests a "floor" for LDL cholesterol levels beyond which further reductions of heart disease risk cannot be achieved. The target LDL cholesterol of <70 mg/dL is based on data extrapolated from RCTs.