Donor-Pi-Acceptor Fluorene Conjugates, Based on Chalcone and Pyrimidine Derivatives: an Insight into Structure-Property Relationship, Photophysical and Electrochemical Properties.

A small set of four new fluorenyl chromophores (5-5a-c) was accomplished by stepwise nucleophilic substitution, Friedel-Crafts acylation, Ullman coupling, aldol condensation and cyclization reactions. The fluorene moiety was substituted at 2,7,9 and 9' positions with diverse groups. The synthesized derivatives were characterized by FTIR, H-NMR and C-NMR spectroscopic techniques.

Synthesis and characterization of DGEBA composites reinforced with Cu/Ag modified carbon nanotubes.

Carbon nanotubes (CNTs) are among the strongest and stiffest contender to be used as filler to elevate the properties of epoxy. The aim of this research work is to evaluate the structural, thermal, and morphological properties of multiwalled carbon nanotubes (MWCNTs) hybridized with silver, copper and silver/copper nanoparticles (Ag/CuNP) obtained via chemical reduction of aqueous salts assisted with sodium dodecyl sulphate (SDS) as stabilizing agent. The MWCNTs/NP was further incorporated in DGEBA (epoxy) using ethyl cellulose as hardener.

1-(2-Hydroxy-5-((trimethylsilyl)ethynyl)phenyl)ethanone based α,β-unsaturated derivatives an alternate to non-sulfonamide carbonic anhydrase II inhibitors, synthesis via Sonogashira coupling, binding analysis, Lipinsk's rule validation.

A novel series of silyl-yne containing chalcone derivatives 5a-5j was synthesized by exploiting Sonogashira coupling reaction and Claisen-Schimdt condensation reaction. The synthesized derivative were characterized by spectroscopic and elemental analysis. The selective inhibition of carbonic anhydrases is considered critical in the field of medicinal chemistry because carbonic anhydrases exits in several isoforms.

Enzyme inhibitory activities an insight into the structure-Activity relationship of biscoumarin derivatives.

Biscoumarin derivatives, a dimeric form of coumarin, are well known derivatives of coumarin, occurred in the bioactive metabolites of marine and terrestrial organisms. On account of pharmacological and biological applications, biscoumarins have long been the subject of innumerable enzyme inhibition studies. In this review the pros and cons of enzyme inhibition studies of biscoumarins as urease inhibitors, aromatase inhibitors, NPPs, α-glucosidase inhibitors, α-amylase inhibitors, HIV-1 integrase inhibition, steroid sulfatase inhibitors and c-Met inhibitors are discussed in a systematic way.

Design and synthesis of 2,6-di(substituted phenyl)thiazolo[3,2-b]-1,2,4-triazoles as α-glucosidase and α-amylase inhibitors, co-relative Pharmacokinetics and 3D QSAR and risk analysis.

Ten fused heterocyclic derivatives bearing the 2,6-di(subsituted phenyl)thiazolo[3,2-b]-1,2,4-triazoles as central rings were synthesized and structures of the compounds were established by analytical and spectral data using FTIR, EI-MS, H NMR and C NMR techniques. In vitro inhibitory activities of synthesized compounds on α-amylase, α-glucosidase and α-burylcholinesterase (α-BuChE) were evaluated using a purified enzyme assays. Compound 5c demonstrated strong and selective α-amylase inhibitory activity (IC=1.

Spectroscopic and electrochemical behavior of newly synthesized high fluorescent symmetric 4'-nitrophenyl-3,4,9,10-perylenebisdiimide-azo hybrid dyes.

The investigation has been made in the synthesis of azo hybrid rylene dyes. The hybridization of perylene bis-diimide with phenolic azo-dyes was carried out by the nucleophilic substitution (SNAr) reaction of tetrachloroperylene-3,4,9,10-bisdiimide 3 with phenolic azo-dyes 4a-g in basic medium. The hybrid dyes exhibited two absorption maxima λmax in the range 300-350, 426-438 nm in ethanol due to presence of azo linkage and highly conjugated framework of π bonds.