Cell proliferation activity delineated by molecular docking of four new compounds isolated from the aerial parts of Forssk. ex. J.F. Gmel.

Using different chromatographic methods, four new compounds were isolated from the aerial parts of (Chenopodiaceae) along with 2-hydroxy-1-naphthoic acid (SCM-3). The structures of the new compounds were established as 6'-hydroxy-10'-geranilanyl naphtha-1-oate (SMC-1), 4,4,8β,10β-Tetramethyl-9β-isobutanyl decalin-13-ol-13-O-β-D-xylopyranoside (SCM-2), 6'-(2-hydroxynaphthalen-3-yl) hexanoic acid (SCM-4) and 1'-(2-Methoxy-3-naphthyl)-4'-(2''-methylbenzoyl)--butane (SMC-5) by IR, EIMS and NMR (1 & 2D) analyses. All compounds (50 μg/mL) were tested for cell proliferative potential on cultured human liver cell HepG2 cells by MTT assay.

Antidiabetic, antioxidant, molecular docking and HPTLC analysis of miquelianin isolated from C. Presl.

The present study demonstrates the miquelianin or quercetin 3--glucuronide (compound ) isolated from aerial parts of exhibited significant results for antioxidant and antidiabetic potential. The compound along with kaempferol 3--glucuronide (compound ) and quercetin 3--rhamnoside (compound ) isolated from the same source were quantified by validated HPTLC method. Antioxidant activity was determined by chemical means in terms of ABTS radical cation and DPPH radical scavenging activity.

Impact of major co-morbidities on mortality and complications after gastric bypass.

Background: We hypothesized that major co-morbidities affect survival and complications after gastric bypass.

Methods: A total of 1465 patients undergoing laparoscopic and open gastric bypass between 1995 and 2002 were studied. Patients with a body mass index >or= 35 kg/m(2) and major co-morbidities (group 1, n = 1045) were compared with patients with a body mass index >or= 40 kg/m(2) with minor/no co-morbidities (group 2, n = 420).