Effect of combination of Beta Glucan and Lactobacillus rhamnosus HerizI on white blood cell counts and serum levels of IL-4 and IL-12 in women with breast cancer undergoing chemotherapy: A randomized double-blind placebo-controlled clinical trial.

Background: Aim of this study was the isolation of native probiotic and determine the effect of combination of Beta Glucan and Lactobacillus rhamnosus Heriz I on White Blood Cell Counts and serum levels of IL-4and IL-12 in breast cancer women receiving Chemotherapy.

Methods: This study was randomized double-blind placebo-controlled clinical trial in 30 women with breast cancer. Women in the intervention group received two 10-mg capsules of soluble 1-3,1-6, D-beta glucan and one capsule of Lactobacillus rhamnosus strain Heriz I (2 × 10 CFU) daily and placebo group received placebo during 21days, interval between two courses of chemotherapy.

The role of tumor suppressor of resveratrol and prednisolone by downregulation of YKL-40 expression in CCRF-CEM cell line.

Background: Acute lymphoblastic leukemia (ALL) is characterized by excessive accumulation of lymphoblast and progenitors. Leukemia is the most common cancer in children and ALL is the most common subtype. Many studies have shown that the YKL-40 gene is one of the most widely expressed genes in tumors, including leukemia, but not in healthy blood cells.

A Comparative Study on the Meaning in Life of Patients with Cancer and Their Family Members.

The overwhelming effects of cancer could be catastrophic for the patients and their family members, putting them at risk of experiencing uncertainty, loss, and an interruption in life. Also, it can influence their sense of meaning, a fundamental need equated with the purpose in life. Accordingly, this study aimed to compare the meaning in life (MiL) of patients with cancer and their family members.

Other Side of Breast Cancer: Factors Associated with Caregiver Burden.

Purpose: This study aimed to determine factors associated with caregiver burden among primary caregivers of women with breast cancer in Iran.

Methods: This was a descriptive correlation study conducted in 2012 on 150 main caregivers of patients with breast cancer who came to the oncology clinic of Shahid Ghazi hospital in Tabriz, Iran. A questionnaire which included caregiving-related factors and the Zarit Burden Interview was used for data collection after its validity and reliability were determined.

Characterization of Common Chromosomal Translocations and Their Frequencies in Acute Myeloid Leukemia Patients of Northwest Iran.

Objective: Detection of chromosomal translocations has an important role in diagnosis and treatment of hematological disorders. We aimed to evaluate the 46 new cases of de novo acute myeloid leukemia (AML) patients for common translocations and to assess the effect of geographic and ethnic differences on their frequencies.

Materials And Methods: In this descriptive study, reverse transcriptase-polymerase chain reaction (RT-PCR) was used on 46 fresh bone marrow or peripheral blood samples to detect translocations t (8; 21), t (15; 17), t (9; 11) and inv (16).

Dosimetric properties of N-isopropylacrylamide polymer gel using nonelectrophoresis grade BIS in preparation.

Introduction: Unlike availability of the different grades of N, N'-methylenebisacrylamide (BIS), electrophoresis is recommended in literature as a crosslinking agent in gel preparation. As the cost of non-electrophoresis grade BIS is much less than that of electrophoresis, the dosimetric characteristics of the of the polymer gel using non-electrophoresis BIS is evaluated in terms of photon energy and dose rate.

Materials And Methods: To compare the response of this gel with the one that contains electrophoresis grade BIS, two sets of N-isopropylacrylamide (NIPAM) gel were prepared using electrophoresis and non-electrophoresis BIS and irradiated to different gamma doses.

Effect of Beta glucan on quality of life in women with breast cancer undergoing chemotherapy: a randomized double-blind placebo-controlled clinical trial.

Purpose: Breast cancer is the most common female malignancy in the world. Beta glucan may improve quality of life in cancer patients receiving chemotherapy. The aim of this trial was to determine the effect of Beta glucan on quality of life in women with breast cancer undergoing chemotherapy.

Risk factors for breast cancer in Iranian women: a hospital-based case-control study in tabriz, iran.

Purpose: Breast cancer is the most common cancer in women worldwide and the leading cause of cancer death among women. In Asian countries such as Iran, the incidence of breast cancer is increasing. The present study aimed to assess the risk factors for breast cancer of women in Tabriz, Iran.

Metastatic malignant melanoma affecting stomach.

Malignant melanoma has been reported to affect all organs of the human body with the metastasis. Stomach metastases are quite rare in cases of the most commonly reported primaries including, melanoma and breast, and lung carcinomas. This report involves, a 56-year-old man suffering from melanoma of the lower extremity that developed into gastric, pulmonary, and brain metastases.

Effect of beta glucan on white blood cell counts and serum levels of IL-4 and IL-12 in women with breast cancer undergoing chemotherapy: a randomized double-blind placebo-controlled clinical trial.

Background: Breast cancer is the most common female malignancy in the world. Beta glucan can be a hematopoietic and an immune modulator agent in cancer patients. The aim of this trial was to determine the effect of beta glucan on white blood cell counts and serum levels of IL-4 and IL-12 in women with breast cancer undergoing chemotherapy.

Nutritional assessment of patients with acute leukemia during induction chemotherapy: association with hospital outcomes.

Cancer-related malnutrition causes morbidity and reduced survival. The aim of this study was to evaluate the nutritional and inflammatory status of patients with acute leukemia in association with duration of neutropenic fever (DNF) and length of hospital stay (LHS) during induction chemotherapy. Fifty-five patients with acute lymphoblastic leukemia (ALL) (n = 28) and acute myeloid leukemia (AML) (n = 27) completed the study.

Survival analysis of breast cancer patients in northwest Iran.

Background: Breast cancer is the most frequently occurring cancer among Iranian women; however limited studies have been conducted to address survival rates.

Objective: The objective was to examine survival rates in Tabriz (Northwest of Iran) and compare with those of data reported from other cities and countries.

Methods: Survival rates were calculated for one, three, five, seven and ten years for 271 breast cancer patients referred to one university clinic during 1997-2008.

Successful management of total knee replacement in a high responder hemophilia patient with a history of inhibitor.

The development of inhibitors against administered clotting factors may render replacement therapy ineffective for some hemophilia patients. Such patients are therefore at the highest risk of developing arthropathy. Elective orthopedic surgery (EOS) in hemophilic patients having such inhibitors remains a rare, expensive, and difficult surgery, whose management represents a significant challenge.

Patterns of metastasis and survival in breast cancer patients: a preliminary study in an Iranian population.

Due to lack of sufficient data on characteristics of breast cancer patients and risk factors for developing metastasis in Iran this study was designed to understand clinical aspects impacting on survival. A cross-sectional study on breast cancer patients was conducted in an oncology clinic of the university hospital between 1995 and 2010. Data were retrieved from medical records and included age, menopausal status, tumor diameter, number of involved nodes, histopathological type, estrogen and progesterone receptor expression, c-erbB-2, primary and secondary metastasis sites, overall survival, disease free interval and type of chemotherapy protocol.

Association of serum level of 25 hydroxy-vitamin D with prognostic factors for breast cancer.

Background And Aim: In recent years, there has been considerable interest in whether vitamin D inhibits breast cancer development. Experimental studies have shown that vitamin D promotes cell differentiation and retards or terminates proliferation of breast cancer cells. However, there is little evidence supporting the association of vitamin D and prognosis of breast cancer.

Myeloperoxidase index and subtypes of acute myeloid leukemia.

Acute myeloid leukemia (AML) should be classified into subtypes according to the French-American-British (FAB) or, preferably, the newer World Health Organization (WHO) classification schemes. FAB is purely a morphological classification. It does not determine treatment (except M3) or prognosis for the patient which requires cytogenetics.

Control of acute myeloid leukemia morbidity in northwest Iran.

Background: To investigate protocols of remission induction therapy for prevention of morbidity of acute myeloid leukemia.

Materials And Methods: The responses of 150 patients to "2+5" and "3+7" protocols during 1996-2003 were assessed and analyzed with the Chi-Square method.

Results: Complete remission was observed in 30% of cases treated with 2 days of daunorubicin and 5 days of cytarabine (2+5 regimen).

Role of myeloperoxidase index in differentiation of megaloblastic and aplastic anemia.

Background: Elevated neutrophil myeloperoxidase may have a role in the diagnosis of megaloblastic erythropoiesis.

Aims: To study the differentiating role of myeloperoxidase index in megaloblastic and aplastic anemia.

Settings And Design: The myeloperoxidase index (MPXI) was studied in 96 patients with megaloblastic and aplastic anemia diagnosed on bone marrow aspiration and biopsy examinations.

High frequency of acute promyelocytic leukemia in northwest Iran.

Acute promyelocytic leukemia (APL) or M3 is a subtype of acute myeloid leukemia, according to the French-American-British group classification. High frequencies of APL have been reported previously by many investigators. We here studied AML patients to determine the frequency of APL in Tabriz in northwest Iran.