Publications by authors named "Jamal Almowalad"
Article Synopsis
- - The study investigated producing zein nanoparticles with encapsulated coumarin-6 using manual techniques compared to a microfluidic system, aimed at improving scale-up and reproducibility issues in nanoparticles manufacture.
- - Both manual and microfluidic methods were tested, but nanoprecipitation produced nanoparticles with better size and drug entrapment efficiency (64%), while microfluidics had lower yield and drug retention.
- - The optimal formulation found was mPEG5K-zein (0.5:1), showing enhanced stability and improved uptake of coumarin-6 by melanoma cells, indicating its potential for effective drug delivery.
Background: The use of gene therapy to treat prostate cancer is hampered by the lack of effective nanocarriers that can selectively deliver therapeutic genes to cancer cells. To overcome this, we hypothesize that conjugating lactoferrin, a tumor-targeting ligand, and the diaminobutyric polypropylenimine dendrimer into gold nanocages, followed by complexation with a plasmid DNA, would enhance gene expression and anti-proliferation activity in prostate cancer cells without the use of external stimuli.
Methods: Novel gold nanocages bearing lactoferrin and conjugated to diaminobutyric polypropylenimine dendrimer (AuNCs-DAB-Lf) were synthesized and characterized.
Background: Gold nanocages have been widely used as multifunctional platforms for drug and gene delivery, as well as photothermal agents for cancer therapy. However, their potential as gene delivery systems for cancer treatment has been reported in combination with chemotherapeutics and photothermal therapy, but not in isolation so far. The purpose of this work was to investigate whether the conjugation of gold nanocages with the cancer targeting ligand lactoferrin, polyethylene glycol and polyethylenimine could lead to enhanced transfection efficiency on prostate cancer cells in vitro, without assistance of external stimulation.
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