Publications by authors named "Jalindar Talode"
Article Synopsis
- Ketones were efficiently produced from thioesters using in-situ generated diarylcuprates(I) with copper(I) salts and aryl Grignard reagents in a controlled environment.
- The synthesis tolerated multiple functional groups, resulting in multifunctionalized ketones with high yields, including intermediates for important pharmaceuticals like canagliflozin and biotin.
- Mechanistic studies indicated the process involved oxidative addition of the C-S bond and reductive elimination from a copper intermediate, leading to the formation of ketones and recycling of the reactive component.
Article Synopsis
- Nickel- and palladium-catalyzed Fukuyama coupling reactions effectively produced multifunctional aryl ketones from a specific thioester and arylzinc reagents at room temperature.
- The study identified 1,2-bis(dicyclohexylphosphino)ethane (dCype) as an excellent ligand to enhance product yields in the nickel-catalyzed reactions.
- Additionally, Pd/C was found to be a convenient alternative for ligand-free reactions, successfully aiding in the production of important diabetic medications like canagliflozin and dapagliflozin.
A regio- and chemoselective cross-coupling study using 2,3-dibromobenzofurans and 2,3,5-tribromobenzofuran was achieved with sub-stoichiometric loadings of triarylbismuths as atom-economic reagents under Pd-catalyzed conditions. As part of this study, various 2,3-diaryl- and 2,3,5-triarylbenzofuran products were obtained in high yields, involving one-pot operations and short reaction times.
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