Single-cell morphodynamical trajectories enable prediction of gene expression accompanying cell state change.

Extracellular signals induce changes to molecular programs that modulate multiple cellular phenotypes, including proliferation, motility, and differentiation status. The connection between dynamically adapting phenotypic states and the molecular programs that define them is not well understood. Here we develop data-driven models of single-cell phenotypic responses to extracellular stimuli by linking gene transcription levels to "morphodynamics" - changes in cell morphology and motility observable in time-lapse image data.

Super-Arrhenius diffusion in a binary colloidal mixture at low volume fraction: an effect of depletion interaction due to an asymmetric barrier.

We report results from the molecular dynamics simulations of a binary colloidal mixture subjected to an external potential barrier along one of the spatial directions at low volume fraction, ϕ = 0.2. The variations in the asymmetry of the external potential barrier do not change the dynamics of the smaller particles, showing Arrhenius diffusion.

Super-Arrhenius diffusion in a binary colloidalmixture at low volume fraction: An effect ofdepletion interaction.

We report results from the molecular dynamics simulations of a binary colloidal mixture subjected to an external potential barrier along one of the spatial directions at low volume fraction, $\phi=$ 0.2. The variations in the asymmetry of the external potential barrier do not change the dynamics of the smaller particles, showing Arrhenius diffusion.

Violation of Stokes-Einstein and Stokes-Einstein-Debye relations in polymers at the gas-supercooled liquid coexistence.

Molecular dynamics simulations are performed on a system of model linear polymers to look at the violations of Stokes-Einstein (SE) and Stokes-Einstein-Debye (SED) relations near the mode coupling theory transition temperatureat three (one higher and two lower) densities. At low temperatures, both lower density systems show stable gas-supercooled-liquid coexistence whereas the higher density system is homogeneous. We show that monomer density relaxation exhibits SE violation for all three densities, whereas molecular density relaxation shows a weak violation of the SE relation nearin both lower density systems.

Phase separation in a two-dimensional binary colloidal mixture by quorum sensing activity.

We present results from Langevin dynamics simulations of a glassy active-passive mixture of soft-repulsive binary colloidal disks. Activity on the smaller particles is applied according to the quorum sensing scheme, in which a smaller particle will be active for a persistence time if its local nearest neighbors are equal to or greater than a certain threshold value. We start with a passive glassy state of the system and apply activity to the smaller particles, which shows a nonmonotonous glassy character of the active particles with the persistence time of the active force, from its passive limit (zero activity).