Publications by authors named "Jalihal Umesh"
Introduction: Proton pump inhibitors (PPIs) regulate gastric acid reflux. Dexlansoprazole's efficacy in prolonging acid suppression compared to conventional PPIs and placebo requires evaluation.
Methods: A prospective, randomized, placebo-controlled, five-way crossover pilot study was conducted on healthy volunteers comparing the potency of dexlansoprazole to conventional PPIs in which five patients were randomized into five treatment cohorts, including dexlansoprazole 60 mg, pantoprazole 40 mg, esomeprazole 40 mg, rabeprazole 20 mg, and placebo, assessing 24-hour intragastric pH using Z/pH Recorder (ZepHr®, Diversatek, Inc.
Article Synopsis
- Hepatorenal syndrome-acute kidney injury (HRS-AKI) is a serious complication of chronic liver disease that leads to high rates of illness and death, and terlipressin, a vasopressin analog, shows promise in treating it by effectively managing blood pressure and reducing side effects during continuous infusion.
- This study evaluated the safety and effectiveness of administering terlipressin at a continuous rate of 4 mg/day in patients with HRS-AKI, involving 136 participants who were monitored for their response to treatment and side effects.
- Results indicated that 69.1% of patients experienced a reduction in serum creatinine levels, with an average treatment duration of 7.6 days, although 21.
Guidelines on optimizing the use of proton pump inhibitors: PPI stewardship.
Indian J Gastroenterol
October 2023
Article Synopsis
- Proton pump inhibitors (PPIs) are widely prescribed medications used for treating gastric acid-related disorders, but concerns about inappropriate usage have emerged over the years.
- There are worries regarding the safety and adverse effects of long-term PPI use, emphasizing the need for better management practices known as PPI stewardship.
- The Indian Society of Gastroenterology has developed guidelines using a modified Delphi process to optimize PPI use and enhance clinician awareness on appropriate indications and durations for prescribing them.
Aims: Irritable bowel syndrome (IBS) is a functional gastrointestinal disorder characterized by impaired gut-brain interaction. Considering the paucity of evidence in the Indian setting, the current study was conducted to determine the sociodemographics, clinical profiles, management practices, and patients' perception among newly diagnosed patients with IBS.
Methods: This was a cross-sectional, single-visit, observational, non-interventional, epidemiological study conducted across 12 centres.
Background/aims: The efficacy and safety of vedolizumab in moderate to severely active ulcerative colitis (UC) have been demonstrated in the GEMINI 1 study (NCT00783718). This post-hoc exploratory analysis sought to establish the efficacy and safety of vedolizumab in a subgroup of patients from Asian countries with UC from GEMINI 1.
Methods: Efficacy outcomes of interest were clinical response, clinical remission and mucosal healing at week 6 (induction phase); and clinical remission, durable clinical response, durable clinical remission, mucosal healing and glucocorticoid-free remission at week 52 (maintenance phase).
Article Synopsis
- The study aims to examine and compare the oral cavity's surface pH levels between patients with gastroesophageal reflux disease (GERD) and healthy individuals.
- Researchers used digital pH meters to assess oral pH at different sites in 34 GERD patients and 32 controls, along with measuring salivary flow rates and buffering capacity.
- Results revealed that GERD patients had a significantly lower average pH (6.65) compared to controls (7.23), with the lowest pH found in the floor of the mouth, indicating potential negative effects on oral health.
Article Synopsis
- * A case study of a patient with NF type 1 showed chronic constipation and colon wall thickening detected through colonoscopy, with a biopsy revealing neural hyperplasia.
- * The report highlights the importance of using minimally invasive endoscopic biopsies to diagnose gastrointestinal issues related to NF1 and discusses other possible diagnoses for gastrointestinal lesions showing neural hyperplasia.
Hookworm infestation in south India--are we moving away from microscope?
Indian J Gastroenterol
January 2013