Publications by authors named "Jalen Brown"
Article Synopsis
- The AS04-adjuvanted HPV16/18 vaccine shows strong effectiveness against targeted HPV types and partial protection against related types, with variations in efficacy observed based on viral lineages and genetic differences.
- In a study involving nearly 8,000 women, the vaccine's effectiveness against HPV31 was significantly lower for lineage-B compared to lineage-A, highlighting the impact of specific genetic variants on vaccine response.
- Findings reveal important implications for global health, indicating that differential vaccine efficacy against various HPV variants could influence cancer risk across different populations and regions.
Background: Transgender and gender diverse (TGD) individuals experience an incongruence between their assigned birth sex and gender identity. They may have a higher prevalence of health conditions associated with cancer risk than cisgender people.
Aim: To examine the prevalence of several cancer risk factors among TGD individuals compared with cisgender individuals.
Importance: Limited prior research suggests that transgender and gender diverse (TGD) people may have higher mortality rates than cisgender people.
Objective: To estimate overall and cause-specific mortality among TGD persons compared with cisgender persons.
Design, Setting, And Participants: This population-based cohort study used data from general practices in England contributing to the UK's Clinical Practice Research Datalink GOLD and Aurum databases.
Background: Chronic hepatitis C virus (HCV) infection can affect immune response and inflammatory pathways, leading to severe liver diseases such as cirrhosis and hepatocellular carcinoma (HCC). Methods: In a prospective cohort of chronically HCV-infected individuals, we sampled 68 individuals who developed cirrhosis, 91 controls who did not develop cirrhosis, and 94 individuals who developed HCC. Unconditional odds ratios (ORs) from polytomous logistic regression models and canonical discriminant analyses (CDAs) were used to compare categorical (C) baseline plasma levels for 102 markers in individuals who developed cirrhosis vs.
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