Publications by authors named "Jalal Ud Din"
In this article, we review a recently published article to explore the significance of foot reflexology in modern medical practice. With the advancement of modern medicine, we are increasingly committed to finding the specific physiological mechanisms of foot reflexes to treat diseases, thereby better proving the therapy's effectiveness. It has been reported that foot reflexes can activate the cerebral cortex and organs corresponding to the feet, stimulating blood flow, nutrition and nerves through neural and endocrine regulation to achieve the purpose of treating and preventing diseases and promoting health.
View Article and Find Full Text PDFThe present study was conducted with the aim to isolate, characterize, and identify the promising zinc-solubilizing rhizobacteria found naturally in the rhizosphere of canola ( L.) plants. The study investigated the roles of these strains in nutrient acquisition and assimilation of extracellular molecules such as hormones and secondary metabolites.
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- GLUT1 deficiency syndrome (GLUT1-DS) is a rare metabolic disorder that affects brain function, leading to various neurological symptoms such as convulsions and movement disorders.
- A study of 15 patients diagnosed with GLUT1-DS showed that all had significant symptoms but improved after following a ketogenic diet (KD) for up to a year, despite none having a typical cerebrospinal fluid glucose ratio.
- The study emphasized the importance of genetic testing, specifically for the solute carrier family 2 member 1 gene variant, as a diagnostic tool, and highlighted the KD as an effective treatment that can enhance the prognosis and quality of life for affected children.
Objective: The current study aimed to observe hypertension educational intervention's effect on general physicians (GPs) to improve blood pressure control and patient outcomes indirectly.
Methods: This randomized control trial includes 42 GPs divided into 2 groups. GPs in group 1 receive face-to-face education with structured educational material on hypertension management strategies by a senior cardiologist.
Conjugation with glucose (G) and fructose (F) via the Maillard reaction under the wet-heating condition is a natural and non-toxic method of improving the technological functions of 7S/11S proteins in different kinds of gels. It may be used as an affordable supply of emulsifiers and an excellent encapsulating matrix for gels. This study aimed to create a glucose/fructose-conjugated 7S/11S soy protein via the Maillard reaction.
View Article and Find Full Text PDFPattern Of Breast Cancer: Experience At Ayub Teaching Hospital, Abbottabad.
J Ayub Med Coll Abbottabad
February 2024
Article Synopsis
- - Breast cancer is the most prevalent cancer among women globally and a major cause of cancer deaths, prompting this study to examine disease presentation patterns in a region lacking proper tumor registry systems.
- - Conducted over a year at Ayub Teaching Hospital, the study included 87 female patients with confirmed breast cancer; findings revealed that 92% had invasive ductal carcinoma, with a significant number showing late-stage disease and common axillary lymph node involvement.
- - The study highlighted the need for improved screening and community education initiatives to foster early detection, along with a call for careful consideration regarding contraceptive hormone use and better data collection for effective care strategies.
Background: Vesical calculi refer to stones in the urinary bladder. The causes of bladder stones include bladder outlet obstruction, neurogenic voiding dysfunction, infection, or foreign bodies. Very rarely, these vesical calculi may reach very large sizes and the largest dimension can sometimes reach 13 centimetres.
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- Nanotechnology plays a crucial role in various scientific fields, particularly through the use of environmentally friendly green-synthesized nanoparticles for applications in agriculture.
- The study focused on creating biogenic silver nanoparticles (Pe-AgNPs) and polyethylene glycol methacrylate coated AgNPs (PEGMA-AgNPs) to enhance biomass in plant tissue culture, showing significant increases in biomass when using these nanoparticles compared to the control.
- Results indicated that both Pe-AgNPs and PEGMA-AgNPs act as effective growth regulators and can stimulate the production of beneficial compounds in plants, supporting their potential use in biotechnology without the need for extensive field cultivation.
Rapid industrialization and global warming have threatened the plants with multiple abiotic stresses, such as heavy metals and drought stress. For crop cultivation, the conventional approach of cleaning the soils by excavation is very costly and not feasible for large scale. Establishing toxin-free and drought-resistant crops is a major challenge in the environment under natural and anthropogenic pressure.
View Article and Find Full Text PDFFrequency Of Hyperuricemia In Subjects With Unstable Angina/Myocardial Infarction And Their Prognosis.
J Ayub Med Coll Abbottabad
November 2022
Article Synopsis
- The study investigates the prevalence of hyperuricemia (high uric acid levels) in patients with acute coronary syndrome (ACS) and its impact on in-hospital outcomes.
- Conducted at Ayub Teaching Hospital from September 2018 to February 2019, the study involved 199 ACS patients, analyzing their uric acid levels and associated complications during hospitalization.
- Results show that 25.13% of patients had hyperuricemia, which was linked to increased cases of cardiogenic shock and other complications, highlighting the need for regular uric acid monitoring in at-risk populations.
Article Synopsis
- Global climate change has led to drought conditions, prompting research into the interactions between endophytic fungal symbionts and plant growth under stress.
- Newly isolated drought-resistant fungal consortia significantly improved various growth metrics (e.g., fresh weight, root length) and increased primary and secondary metabolites in plants exposed to drought stress.
- The combined inoculation also enhanced antioxidant enzyme activities and improved overall plant resilience, reflected in larger stomatal apertures and reduced water potential decline.
Fermentation of available sugars in milk by yogurt starter culture initially and later by (Probiotic yeast) improves the bioavailability of nutrients and produces bioactive substances and volatile compounds that enhance consumer acceptability. The combination of , a unique species of probiotic yeast, and inulin, an exopolysaccharide used as a prebiotic, showed remarkable probiotic and hydrocolloid properties in dairy products. The present study was designed to study the effect of fermentation and storage on antioxidant and volatile capacities of probiotic and synbiotic yogurt by incorporation of and inulin at 1%, 1.
View Article and Find Full Text PDFLactiplantibacillus is among the most extensively studied bacterial specie belonging to the genus Lactobacillus with proven probiotic and health promoting effects. These beneficial effects are generally strains specific but the underlying molecular mechanisms are still not fully understood. Dissecting the determinants behind probiotic topographies of this bacterium is of particular interest since it would help select strains that stand the best chance of success in clinical trials and potential industrial applications.
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- * This study demonstrated that L. plantarum 12-3 can transform LA at different concentrations, resulting in eight distinct fatty acid derivatives, identified using gas chromatography and mass spectrometry.
- * Genome analysis revealed potential enzymes responsible for this conversion, providing insights into how these probiotics may produce health-beneficial metabolites for functional food applications.
Article Synopsis
- The study aimed to extract β-conglycinin (7S) and glycinin (11S) from various soybean sources and compare their yields and purities.
- Modified extraction methods improved yields significantly, especially for the 11S fraction in soybean seeds and meals, leading to nearly doubled outcomes.
- These findings offer new insights into the separation and purification techniques of soybean proteins, which could enhance their applications in the food industry.
Association study of rs3093024 with Rheumatoid Arthritis in a Pakistani cohort.
Saudi J Biol Sci
December 2020
Article Synopsis
- - A study investigated the association of the CCR6 gene variant rs3093024 with rheumatoid arthritis (RA) in 500 Pakistani individuals (250 RA patients and 250 healthy controls), finding significant differences in genotype and allele frequencies between the two groups.
- - The results indicated that the A variant of rs3093024 is linked to increased RA risk, while the G variant appears to be protective; a particular focus was placed on the increased AA genotype in patients compared to AG + GG genotypes.
- - Bioinformatics analysis suggested that the rs3093024 variant could affect gene splicing, potentially impacting the gene's function, leading to recommendations for larger studies and functional research to better understand these findings.
Article Synopsis
- * Through the use of GC-MS, researchers identified and measured 9 different fatty acid analogues produced by L. plantarum K25, with the first-time report of linolenic acid formation occurring in a medium containing 9% linoleic acid.
- * In silico analyses identified candidate enzymes in L. plantarum K25 that may facilitate the conversion of linoleic acid to its analogues, including linoleate isomerase and dehydrogenase, which
Article Synopsis
- - The study investigated how soybean protein hydrolysates affect intracellular antioxidant activity by examining their impact on reactive oxygen species (ROS) production in HepG2 cells.
- - Researchers extracted and sequenced soybean peptides and found that these peptides could inhibit ROS production while promoting the expression of antioxidant enzymes and the Nrf2 protein, which plays a key role in cellular defense against oxidative stress.
- - The findings suggest that soybean peptides trigger a protective response by activating the Nrf2 pathway, enhancing the body's antioxidant capabilities, and potentially reducing oxidative damage.
Lactobacillus plantarum YW11 capability to convert linoleic acid into conjugated linoleic acid and other metabolites was studied in a dose-dependent manner by supplementing LA at different concentrations. L. plantarum YW11 displayed a uniform distinctive growth curve of CLA and other metabolites at concentrations of LA ranging from 1% (w/v) to 10% (w/v), with slightly increased growth at higher LA concentrations.
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- Cancer is a complex disease influenced by multiple genes, with TOX3 gene SNPs linked to breast cancer risk.
- The study identifies several damaging nonsynonymous SNPs (like A266D and P273S) and premature stop codon SNPs (like Q527STOP) that could lead to dysfunctional proteins.
- Additionally, regulatory SNPs affecting TOX3 gene regulation were discovered, and 3D models of the TOX3 protein were created, highlighting the potential for these SNPs in personalized medicine approaches for breast cancer.
Article Synopsis
- A unique probiotic yeast strain (CNCM I-745) was used in the development of a synbiotic yogurt, incorporating varying percentages of inulin (1%, 1.5%, and 2%).
- The study evaluated various properties of the yogurt, including texture, microbial content, and flavor profile, finding that the synbiotic yogurt had enhanced microstructure and a higher number of volatile compounds compared to plain and probiotic yogurts.
- Results showed that 1% inulin improved texture, sensory qualities, reduced moisture separation, and maintained the viability of the probiotic yeast after 28 days, making the yogurt a potential health-benefiting product.
Article Synopsis
- The study examined the prevalence and severity of iron deficiency anemia (IDA) among school-aged children in District Tank from September 2014 to April 2015.
- Blood samples were collected through random sampling and analyzed using the Sysmex Kx-21 Stromatolyser, alongside questionnaires for general information.
- The results showed an overall anemia prevalence rate of 37.1%, with higher rates in boys (63.8%) and girls (64.3%).
Background: Cardiac Troponins are established markers of myocardial injury; however, they may be elevated in chronic renal failure (CRF) patients even in absence of acute myocardial infarction. The objective of the study was to determine the frequency of elevated Troponin T in patients of chronic renal failure without clinically suspected acute myocardial infarction.
Methods: This cross-sectional study was conducted at Medical B Unit of Ayub Teaching Hospital, Abbottabad from 16th December 2013 to 16th June 2014.
Identification of most damaging nsSNPs in human CCR6 gene: In silico analyses.
Int J Immunogenet
December 2019
Single nucleotide polymorphisms in CCR6 (C-C chemokine receptor type 6) gene have been found to be the possible cause of many diseases like rheumatoid arthritis, psoriasis, lupus nephritis and systemic sclerosis and other autoimmune diseases. Therefore, identification of structurally and functionally important polymorphisms in CCR6 is important in order to study its potential malfunctioning and discovering therapeutic targets. Several bioinformatics tools were used to identify most damaging nsSNPs that might be vital for CCR6 structure and function.
View Article and Find Full Text PDFAims: Current study was aimed to produce nitrogen fixing sp. (SR-4) and phosphorus solubilizers () and to evaluate their efficiency as biofertilizers for agricultural practices.
Methods: Two biofertilizer including nitrogen fixing and phosphorus solubilizing were grown.