ROS production by cytochrome bc: Its mechanism as inferred from the effects of heme b cofactor mutants.

Cytochrome bc is one of the enzymes of electron transport chain responsible for generation of reactive oxygen species (ROS). While ROS are considered to be products of side reactions of quinol oxidation site (Q), molecular aspects of their generation remain unclear. One of them concerns significance of hemes b (b and b) redox potentials (E) and properties on ROS generation by Q.

ROS signaling capacity of cytochrome bc: Opposing effects of adaptive and pathogenic mitochondrial mutations.

Cytochrome bc, also known as mitochondrial complex III, is considered to be one of the important producers of reactive oxygen species (ROS) in living organisms. Under physiological conditions, a certain level of ROS produced by mitochondrial electron transport chain (ETC) might be beneficial and take part in cellular signaling. However, elevated levels of ROS might exhibit negative effects, resulting in cellular damage.