Hydrogen storage with gravel and pipes in lakes and reservoirs.

Climate change is projected to have substantial economic, social, and environmental impacts worldwide. Currently, the leading solutions for hydrogen storage are in salt caverns, and depleted natural gas reservoirs. However, the required geological formations are limited to certain regions.

Teloxantron inhibits the processivity of telomerase with preferential DNA damage on telomeres.

Telomerase reactivation is one of the hallmarks of cancer, which plays an important role in cellular immortalization and the development and progression of the tumor. Chemical telomerase inhibitors have been shown to trigger replicative senescence and apoptotic cell death both in vitro and in vivo. Due to its upregulation in various cancers, telomerase is considered a potential target in cancer therapy.

Novel chalcone-derived pyrazoles as potential therapeutic agents for the treatment of non-small cell lung cancer.

Lung cancer is considered to account for approximately one-fifth of all malignant tumor-related deaths worldwide and is therefore one of the most lethal malignancies. Pyrazole scaffold possesses a wide range of biological and pharmacological activities, which play important roles in medicinal chemistry. The present study reports the synthesis and in vitro biological characterization of nine pyrazoles derived from chalcones as potential anticancer agents for non-small cell lung cancer A-549, H226, and H460 cell lines.

Molecular mechanism of proton-coupled ligand translocation by the bacterial efflux pump EmrE.

The current surge in bacterial multi-drug resistance (MDR) is one of the largest challenges to public health, threatening to render ineffective many therapies we rely on for treatment of serious infections. Understanding different factors that contribute to MDR is hence crucial from the global "one health" perspective. In this contribution, we focus on the prototypical broad-selectivity proton-coupled antiporter EmrE, one of the smallest known ligand transporters that confers resistance to aromatic cations in a number of clinically relevant species.

Quest for the Molecular Basis of Improved Selective Toxicity of Isomers of Aromatic Heptaene Macrolide Antifungal Antibiotics.

Three aromatic heptaene macrolide antifungal antibiotics, Candicidin D, Partricin A (Gedamycin) and Partricin B (Vacidin) were subjected to controlled photochemical isomerization. The obtained isomers demonstrated substantially improved in vitro selective toxicity in the cells: human erythrocytes model. This effect was mainly due to the diminished hemotoxicity.

The impact of long-term changes in air temperature on renewable energy in Poland.

This paper analysed from the statistical point of view the trends in observed air temperature in major Polish cities and presented a qualitative analysis of their potential impact on the operation of the selected renewable energy sources. It also reviews the relation between the air temperature and observed electrical load as well as changing numbers of cooling and heating degree days. The method involved a statistical analysis of historical mean daily temperature observed in 19 major Polish cities over the 1968-2018 period.

Spatial representation of temporal complementarity between three variable energy sources using correlation coefficients and compromise programming.

Renewable energy sources have shown remarkable growth in recent times in terms of their contribution to sustainable societies. However, integrating them into the national power grids is usually hindered because of their weather-dependent nature and variability. The combination of different sources to profit from their beneficial complementarity has often been proposed as a partial solution to overcome these issues.