ApisTox: a new benchmark dataset for the classification of small molecules toxicity on honey bees.

The global decline in bee populations poses significant risks to agriculture, biodiversity, and environmental stability. To bridge the gap in existing data, we introduce ApisTox, a comprehensive dataset focusing on the toxicity of pesticides to honey bees (Apis mellifera). This dataset combines and leverages data from existing sources such as ECOTOX and PPDB, providing an extensive, consistent, and curated collection that surpasses the previous datasets.

Immunologic analysis of CSF in patients with de novo diagnosed RRMS. The role of chemokines in the early phase of the disease.

Objectives: Multiple sclerosis (MS) is a chronic CNS autoimmune disease characterized by demyelination and neurodegeneration. Chemokines regulate leukocyte migration and inflammation in MS. In the present study, we evaluated selected chemokine levels in the cerebrospinal fluid of patients with multiple sclerosis diagnosed de novo compared to healthy controls.

Relation between skin temperature and muscle stiffness in masters athletes: Effect of specific training adaptation.

Aging process is correlated with negative changes in muscles properties such as their thermal responsiveness and stiffness. At the same time masters athletes are often considered as an exemplars of successful aging. Taking this into account, the aim of the study was to establish thermal portrait of lower limbs in Masters Athletes in Track & Field competing in 200 m race as well as to find out the effect of exercise on muscle stiffness.

Fluorescence spectral analysis and logistic regression modeling for diagnosing basal cell carcinoma on head and neck.

The optical fluorescence method is distinguished by key features such as non-invasiveness, high sensitivity, and resolution, which are superior to traditional diagnostic approaches. Unlike histopathological examinations and biochemical analyses, optical diagnostic methods obviate the need for tissue sampling, enabling the analysis of virtually unlimited material. The research aims to examine the effectiveness of emission spectra analysis in the diagnosis of basal cell carcinoma (BCC) of the scalp and neck.

Mitochondrial Genome Variation in Polish Elite Athletes.

Energy efficiency is one of the fundamental athletic performance-affecting features of the cell and the organism as a whole. Mitochondrial DNA (mtDNA) variants and haplogroups have been linked to the successful practice of various sports, but despite numerous studies, understanding of the correlation is far from being comprehensive. In this study, the mtDNA sequence and copy number were determined for 99 outstanding Polish male athletes performing in power (n = 52) or endurance sports (n = 47) and 100 controls.

A comprehensive health effects assessment of the use of sanitizers and disinfectants during COVID-19 pandemic: a global survey.

COVID-19 has affected all aspects of human life so far. From the outset of the pandemic, preventing the spread of COVID-19 through the observance of health protocols, especially the use of sanitizers and disinfectants was given more attention. Despite the effectiveness of disinfection chemicals in controlling and preventing COVID-19, there are critical concerns about their adverse effects on human health.

THE MOST COMMON UROLOGICAL CONDITIONS IN POSTMENOPAUSAL WOMEN.

Objective: The aim: To analyze the available literature on the most common daily urological problems in menopausal women and to evaluate the use of hormone replacement therapy for troublesome urological symptoms.

Patients And Methods: Materials and methods: Analysis of publications from PubMed databases on the most common disorders during menopause was performed and the most common urog¬ynaecological problems in postmenopausal women were selected according to literature data. Different available methods of treatment of these disorders were compared.

Transmission Distortion of MCT1 rs1049434 among Polish Elite Athletes.

Background: To date, nearly 300 genetic markers were linked to endurance and power/strength traits. The current study aimed to compare genotype distributions and allele frequencies of the common polymorphisms: rs1049434, rs12594956, rs1052373 and rs1799945 in Polish elite athletes versus nonathletes.

Methods: The study involved 101 male elite Polish athletes and 41 healthy individuals from the Polish population as a control group.

Does predicted age at peak height velocity explain physical performance in U13-15 basketball female players?

Background: The aims of the study were (1) to identify the physical fitness and basic anthropometric characteristics of Polish female basketball players aged 13-15 years, (2) to show the effect of maturity timing on the performance in motor tests and basic body composition parameters, (3) to identify the index that contributes most to the prediction of performance in the tests of speed, jumping ability, agility, and endurance.

Methods: The sample included 904 female Polish players (U13-15). In part 1, maturity timing category distribution were examined within across age-groups.

Rare Variant in the SLC6A2 Encoding a Norepinephrine Transporter Is Associated with Elite Athletic Performance in the Polish Population.

Numerous genetic factors have been shown to influence athletic performance, but the list is far from comprehensive. In this study, we analyzed genetic variants in two genes related to mental abilities, rs1805065) and (rs2635438) in a group of 890 athletes (320 endurance, 265 power, and 305 combat athletes) vs. 1009 sedentary controls.

Bone mineral density in elite masters athletes: the effect of body composition and long-term exercise.

Background: The purpose of the study was to examine how bone mineral density (BMD) is related to body composition depending on the practiced sport (endurance, speed-power, throwing sports) in participants of the World Masters Athletics Championship.

Methods: Dual-energy X-ray absorptiometry (DXA) was used to determine BMD and bone mass (BMC). Body composition was analyzed by means of the JAWON Medical X-scan analyzer using bioelectrical impedance methods.

The Second-to-Fourth Digit (2D:4D) Ratio of Male Combat Athletes is Associated with the Choice of Sport.

The second-to-fourth-digit (2D:4D) ratio has been widely used as a putative marker of prenatal exposure to testosterone in health, behavioral and sport sciences, but it has only been used few times regarding combat athletes. This study involved 200 male elite combat athletes (Olympic wrestling, kickboxing, judo, taekwondo and karate) and 179 males not participating in any sports. The lengths of the index finger (2D) and ring (4D) finger were measured using computer-assisted image analysis (AutoMetric 2.

To Be a Champion of the 24-h Ultramarathon Race. If Not the Heart ... Mosaic Theory?

This comprehensive case analysis aimed to identify the features enabling a runner to achieve championship in 24-h ultramarathon (UM) races. A 36-year-old, multiple medalist of the World Championships in 24-h running, was assessed before, one and 10 days after a 24-h run. Results of his extensive laboratory and cardiological diagnostics with transthoracic echocardiography (TTE) and a one-time cardiopulmonary exercise test (CPET) were analyzed.

Common Myelin Regulatory Factor Gene Variants Predisposing to Excellence in Sports.

In all sport disciplines, excellent coordination of movements is crucial for achieving mastery. The ability to learn new motor skills quickly and effectively is dependent on efficient myelination which varies between individuals. It has been suggested that these differences may play a role in athletic performance.

Clinical and Radiological Evaluation of Results of Surgical Correction of Forefoot Adduction by Cuneiform and Cuboid Osteotomy Using Radiological Forefoot Measurements.

Background: Forefoot adduction is a relatively common problem. It is usually mild or it can be effectively managed conservatively. Severe deformities may require surgical treatment.

Bone Mineral Density in Adolescent Boys: Cross-Sectional Observational Study.

Physical inactivity of children can be a precursor of reduced bone mineral density, considered to be a typical problem only in old age. The aim of this study was to evaluate bone mineral density in 96 Polish boys aged 14-17 years with varied physical activity (swimmers, track and field athletes, non-athletes) and the effect of bone composition, birth weight and breastfeeding during infancy on bone parameters. Anthropometric and body composition measurements were performed according to the kinanthropometric standards.

Changes in the Hormonal Profile of Athletes following a Combat Sports Performance.

Results: Following fighting, the adrenaline concentration was significantly higher in all athletes, most markedly in K ( < 0.001). Baseline cortisol and BDNF levels did not differ among the groups and rose significantly in all the groups after the performance.

Methods of spectral diagnostics in modern prevention of oncological diseases.

This paper contains structured information on photodynamic diagnostics. Photodynamic diagnostics is a young diagnostic modality used in the detection of pre-neoplastic and very early neoplastic lesions. A characteristic feature of the presented method is its completely non-invasive nature and thus the possibility of multiple repetitions at the same patient.

Spectral analysis of basal cell cancer in vivo.

One of the most important features of optical biopsy methods is its non-invasive nature, high sensitivity and resolution in comparison to traditional diagnostic methods. Optical diagnostic methods, contrary to histopathological tests and biochemical analysis, do not require the collection of tissue samples for analysis, and the amount of analyzed material is practically unlimited. The aim of this study was to evaluate the usefulness of spectral studies in the diagnostics of skin basal cell cancer using a protoptive device in clinical conditions.

Does the type of foam roller influence the recovery rate, thermal response and DOMS prevention?

Purpose: Supporting post-exercise recovery requires choosing not only the right treatment but also the equipment, in which the impact is not always clear. The study aimed to determine the effect of foam rolling on the rate of lactate removal and DOMS prevention and whether the type of foam roller is effective in the context of post-exercise recovery.

Methods: This randomized trial enrolled 33 active healthy males divided into three groups of eleven individuals: foam rolling with a smooth (STH) or grid roller (GRID) or passive recovery (PAS).

Assessment of the Health-Related Behaviors of Men Practicing Combat Sports and Martial Arts.

Background: Physical activeness is one of the main elements of lifestyle in terms of preventing civilization diseases. The main purpose of this study was to assess the selected health behaviors of men practicing combat sports and martial arts and to find out what features or variables may have an influence one's lifestyle.

Methods: Overall, 561 men aged 17-35 yr were enrolled and divided into three groups.