Publications by authors named "Jakobsen M"

Background: Psychosocial hazards in the workplace contribute to mental disorders, cardiovascular diseases, and musculoskeletal ill-health. The Hierarchy of Controls applied to NIOSH Total Worker Health (TWH HOC) aims to mitigate these hazards through effective interventions. This study proposes a revision of the model resulting in a HOC for psychosocial hazards (P-HOC) and explores its application in improving the working environment.

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Purpose: Work-related musculoskeletal disorders are prevalent among healthcare workers. These workers experience high rates of low-back pain; partly due to the high physical demands of patient transfers. Understanding the specific transfer scenarios that contribute to high physical loads is therefore crucial for developing strategies to improve working conditions.

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Despite considerable treatment advances, multiple myeloma (MM) remains an incurable hematological cancer due to treatment resistance. A systematic literature search was conducted to identify determinants for clonal evolution driving relapse and drug resistance in MM. A total of 631 non-duplicate publications were screened of which 28 articles were included for data extraction.

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Background: Although potatoes are considered a dietary staple in some cultures, evidence suggests that their impact on type 2 diabetes (T2D) risk is nuanced, with preparation methods and dietary patterns playing crucial roles. Investigating the substitution effects of replacing potatoes with other foods is required to inform dietary recommendations for lowering T2D risk.

Objective: The objective of this was to investigate associations between the substitution of potatoes (excluding fries/chips) with other food groups (vegetables, whole grains, refined grains, red meat, processed meat, poultry, fish, and dairy) and the risk of T2D.

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Background: Oxygen therapy is commonly administered to patients with acute cardiovascular conditions during hospitalisation. Both hypoxaemia and hyperoxia can cause harm, making it essential to maintain oxygen saturation (SpO) within a target range. Traditionally, oxygen administration is manually controlled by nursing staff, guided by intermittent pulse oximetry readings.

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We study the impact of optical aberrations in underwater scanning confocal inelastic imaging arising from refraction at oblique incidences on a refractive index-mismatched air-glass-water interface. We experimentally demonstrate that optical aberrations at non-normal incidence drastically reduce the intensity of the inelastic signal and deteriorate the system resolution. At a 2.

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Purpose: Low-back pain (LBP) is a prevalent condition among healthcare workers, negatively affecting well-being and work ability. Research has identified fear-avoidance beliefs, i.e.

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Over the past decade, it has become clear that the stimulator of interferon genes (STING) pathway is critical for a variety of immune responses. This endoplasmic reticulum-anchored adaptor protein has regulatory functions in host immunity across a spectrum of conditions, including infectious diseases, autoimmunity, neurobiology and cancer. In this Review, we outline the central importance of STING in immunological processes driven by expression of type I and III interferons, as well as inflammatory cytokines, and we look at therapeutic options for targeting STING.

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Cancer/testis antigens (CTAs) are widely expressed in melanoma and lung cancer, emerging as promising targets for vaccination strategies and T-cell-based therapies in these malignancies. Despite recognizing the essential impact of intratumoral heterogeneity on clinical responses to immunotherapy, our understanding of intratumoral heterogeneity in CTA expression has remained limited. We employed single-cell mRNA sequencing to delineate the CTA expression profiles of cancer cells in clinically derived melanoma and lung cancer samples.

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Aim: To explore registered nurses' experiences with pain management in patients with opioid use disorder (OUD) in home care.

Design: Qualitative explorative-descriptive design.

Methods: Data were collected via nine individual semi-structured interviews with registered nurses working in home care meeting patients with OUD.

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Background: Intensive inpatient treatment programs have shown robust results in the treatment of post-traumatic stress disorder (PTSD). How patients experience this treatment program and what changes they experience as a result of the treatment have, however, only scarcely been explored through qualitative studies.

Objective: This study aimed to explore the lived experience of participants in an intensive inpatient trauma treatment program.

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Extensive research has explored the role of gut microbiota in colorectal cancer (CRC). Nonetheless, metatranscriptomic studies investigating the functional implications of host-microbe interactions in CRC are scarce. Therefore, we characterized the influence of CRC core pathogens and biofilms on the tumor microenvironment (TME) in 40 CRC, paired normal, and healthy tissue biopsies using fluorescence hybridization (FISH) and dual-RNA sequencing.

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Article Synopsis
  • X-ray Free Electron Lasers (XFELs) enhance crystallography by enabling high-quality data collection at unprecedented speeds, particularly with the upcoming megahertz superconducting FELs.
  • Traditional gas dynamic virtual nozzles (GDVNs) are limited due to high sample consumption, making them impractical for some protein studies while a new droplet-on-demand injection method shows promise with significantly lower consumption.
  • The study achieved a collection rate of 150,000 indexed patterns per hour at the European XFEL, yielding impressive lysozyme crystallography data at 1.38 Å resolution, marking a significant advancement in protein structure analysis.
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Background: Socioeconomic status as measured by education, income, or occupation, has been associated with fibromyalgia but the underlying mechanism and the role of lifestyle factors are unclear. Thus, we examine the role of modifiable lifestyle factors (body mass index, physical activity, alcohol consumption and smoking) in the association between education and self-reported fibromyalgia.

Methods: We used data from 74,157 participants in the population-based prospective Norwegian Women and Cancer (NOWAC) study.

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Vibration-based Condition Monitoring (CM) is an essential tool for identifying potential defects in industrial machinery. However, the implementation of an efficient CM system often necessitates the use of high-cost accelerometers with a large bandwidth. To address this challenge, this study introduces a low-cost CM sensor composed of an ultrasonic MEMS microphone - SPH0641LU and an ADXL1002 MEMS accelerometer.

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The cGAS-STING pathway plays a crucial role in anti-tumoral responses by activating inflammation and reprogramming the tumour microenvironment. Upon activation, STING traffics from the endoplasmic reticulum (ER) to Golgi, allowing signalling complex assembly and induction of interferon and inflammatory cytokines. Here we report that cGAMP stimulation leads to a transient decline in ER cholesterol levels, mediated by Sterol O-Acyltransferase 1-dependent cholesterol esterification.

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Article Synopsis
  • Work-related musculoskeletal disorders (WMSDs) in the low back and neck/shoulder areas are significant issues for masons due to their repetitive tasks and high physical demands.
  • The study aimed to objectively measure the physical workload of masons during bricklaying at various working heights (knee, hip, shoulder, above shoulder) using tools like surface electromyography and inertial sensors.
  • Results showed that muscle activation in the erector spinae and trapezius muscles varied significantly with working height, indicating increased strain at higher heights, while lower heights were associated with reduced muscle activation.
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Aim: We investigated associations between body mass index (BMI) z-scores for children aged 0-2 years and the BMI z-scores, body fat percentage and metabolic risk factors at 3 years of age.

Methods: This was a secondary analysis of the Lifestyle in Pregnancy and Offspring randomised controlled trial, carried out at two university hospitals in Denmark. It comprised 149 mothers with BMI ≥30 kg/m who did or did not receive a lifestyle intervention during pregnancy and a reference group of 97 mothers with normal-weight, with follow-up of their 3-year-old offspring.

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Clozapine is the gold standard for treating treatment-resistant schizophrenia although continuously underutilized. Previous surveys of clinicians have found that some of the most frequently cited barriers to clozapine prescribing are related to the blood-monitoring requirements. However, these surveys tend to explore general perspectives and may not reflect the true impact of different barriers in real-world outpatient settings.

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ECT is generally regarded as a safe and efficient treatment. In this case report, a 76-year-old female patient did not wake up as expected after ECT. The patient was transferred to the emergency department, and a CT-scan showed an intracerebral haemorrhage.

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Consumption of linseeds has been suggested to have beneficial effects on human health. However, toxic constituents of linseed may compromise these benefits. We conducted a quantitative risk-benefit assessment to evaluate the overall health impact of increasing linseed intake up to 45 g/day in the Danish population (15-74 years).

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Background: Hypoglycemia is common in insulin-treated type 2 diabetes (T2D) patients, which can lead to decreased quality of life or premature death. Deep learning models offer promise of accurate predictions, but data scarcity poses a challenge. This study aims to develop a deep learning model utilizing transfer learning to predict hypoglycemia.

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Musculoskeletal disorders of the upper extremity are among the most common occupational problems affecting nurses. The aim of this study was to analyze the prospective association between vitality and mental health and increased upper extremity pain intensity in female hospital nurses during a 1-year follow-up. A prospective cohort of 1185 female nurses from 19 hospitals in Denmark was conducted using baseline and 12-month follow-up questionnaires to identify potential associations between levels of vitality and mental health (SF-36 subscales) with pain intensity (0-10 scale) in the shoulder, elbow and hand/wrist regions.

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The paper presents the design and high-fidelity prototype of the remote patient self-monitoring system using a combination of intelligent phonocardiography, mobile and web-based platforms. The advantage of self-monitoring is patient awareness about potential changes, the convenience of performing the measurement often, and the saving of the findings. A mobile platform enables a physician to see the data, get a summary of patient recordings, and as well as saving the data.

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Background: While the aetiology of fibromyalgia syndrome (FM) remains unknown, lifestyle factors have been linked to the disorder. However, there are few studies on the association between lifestyle factors and FM, thus we examine the risk of self-reported fibromyalgia given selected lifestyle factors.

Methods: We used data from 75,485 participants in the Norwegian Women and Cancer study.

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