Publications by authors named "Jakob Weidmann"
Pathol Res Pract
May 2024
Article Synopsis
- - The "smoker's paradox" describes how smokers experience a greater effectiveness of the antiplatelet drug clopidogrel compared to non-smokers, likely due to tobacco smoke inducing specific enzymes (CYP1A2 and CYP2C19) that affect drug metabolism.
- - Genetic factors, including ethnic differences and specific gene variants, play a significant role in how individuals respond to clopidogrel, highlighting the complexity and individuality of the smoker's paradox.
- - The review also compares clopidogrel's efficacy with other antiplatelet drugs like prasugrel and ticagrelor, which show more consistent effects, and discusses the importance of personalized treatment based on patient characteristics and smoking status to
