Publications by authors named "Jakob Lykke Lindhardt"
Purpose: Hyperpolarized [1- C]pyruvate MRS can measure cardiac metabolism in vivo. We investigated whether [1- C]pyruvate MRS could predict left ventricular remodeling following myocardial infarction (MI), long-term left ventricular effects of heart failure medication, and could identify responders to treatment.
Methods: Thirty-five rats were scanned with hyperpolarized [1- C]pyruvate MRS 3 days after MI or sham surgery.
Article Synopsis
- * In the study, veno-occlusive unloading significantly decreased myocardial infarct size (13.9% vs. 22.4%) and improved myocardial salvage rates compared to control groups (54.8% vs. 28.5%).
- * The unloaded pigs maintained better left ventricular ejection fraction, suggesting that this approach could be a promising adjunctive therapy for patients undergoing revascularization for acute myocardial infarction.
Renal ischemia-reperfusion injury (IRI) is one of the most common types of acute kidney injury. Spironolactone has shown promising kidney protective effects in renal IRI in rats. We investigated the hemodynamic and metabolic effects of spironolactone (100 mg/kg) administered immediately after 40 min unilateral kidney ischemia in rats.
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