Publications by authors named "Jakob Lesniak"
Biochemistry
December 2004
Article Synopsis
- Linker histone H1B was identified as a coeluting protein with antiviral activity during the purification of the HIV-1 resistance factor (HRF) from cell supernatants.
- Analysis showed that the presence of H1B correlated with HIV-1 resistance, as silencing H1B significantly reduced the antiviral activity of HRF(+) cell supernatants.
- The study suggests that ubiquitinated H1B may act as a cofactor for HRF, influencing its expression and secretion from CD4(+) T cells, which becomes crucial in resisting HIV-1 infection.
