Publications by authors named "Jakeline S Oliveira"
Article Synopsis
- MicroRNAs play a key role in regulating gene expression, with muscle-specific miRNAs influencing muscle characteristics and responses.
- miR-155 is linked to muscular dystrophy and muscle atrophy but its exact functions and targets in these conditions are not fully understood.
- This study identifies that miR-155-5p alters the expression of 359 genes in muscle cells, affecting pathways related to metabolism, cell cycle, muscle maintenance, and immune response, particularly increasing M2 macrophages in dystrophic muscles.
Three genes encoding mitochondrial uncoupling proteins (UCPs) have been described in Arabidopsis thaliana (UCP1 to UCP3). In plants, UCPs may act as an uncoupler or as an aspartate/glutamate exchanger. For instance, much of the data regarding UCP functionality were obtained for the UCP1 and UCP2 isoforms compared with UCP3.
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- Computed tomography (CT) can identify muscle loss in non-small cell lung cancer (NSCLC) patients, but there's no agreed-upon standard for determining muscle loss severity via pectoralis muscle area (PMA) cutoffs.
- A study used machine learning to predict muscle loss and assess clinical features and tumor profiles in NSCLC patients, analyzing data from 211 treatment-naive patients and validating findings with a separate group of 36.
- Results showed that lower PMA was linked to a nearly double risk of death, and specific gene expressions were associated with inflammatory processes, highlighting the importance of muscle status in patient prognosis and disease progression.
Interleukin-6 (IL-6) is a pro-inflammatory cytokine associated with skeletal muscle wasting in cancer cachexia. The control of gene expression by microRNAs (miRNAs) in muscle wasting involves the regulation of thousands of target transcripts. However, the miRNA-target networks associated with IL6-induced muscle atrophy remain to be characterized.
View Article and Find Full Text PDFPancreatic ductal adenocarcinoma (PDAC) is extremely aggressive, has an unfavorable prognosis, and there are no biomarkers for early detection of the disease or identification of individuals at high risk for morbidity or mortality. The cellular and molecular complexity of PDAC leads to inconsistences in clinical validations of many proteins that have been evaluated as prognostic biomarkers of the disease. The tumor secretome, a potential source of biomarkers in PDAC, plays a crucial role in cell proliferation and metastasis, as well as in resistance to treatments, which together contribute to a worse clinical outcome.
View Article and Find Full Text PDFDuplication of the short arm of chromosome 12 is a rare chromosomal abnormality that may arise de novo or result from malsegregation of a balanced parental translocation. This study comprises the clinical description, cytogenetic and cytogenomic analyses and genotype-phenotype correlation in a patient with facial dysmorphism, developmental delay and intellectual impairment caused by non-mosaic partial duplication and a paracentric inversion 12p. The patient's GTG-banded karyotype was 46,XX,invdup(12)(pter → p13.
View Article and Find Full Text PDFCancer cachexia is a multifactorial syndrome that leads to significant weight loss. Cachexia affects 50%-80% of cancer patients, depending on the tumor type, and is associated with 20%-40% of cancer patient deaths. Besides the efforts to identify molecular mechanisms of skeletal muscle atrophy-a key feature in cancer cachexia-no effective therapy for the syndrome is currently available.
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