Publications by authors named "Jake Peter Mann"
Article Synopsis
- The study focused on understanding long-term outcomes in children with intestinal failure (IF), aiming to identify patient characteristics linked to various health endpoints.
- Data from 175 cohorts, involving over 9,300 patients, revealed an overall mortality rate of 5.2% per year, with sepsis and liver disease being significant contributing factors.
- The findings suggest that improving management of sepsis could reduce mortality and liver failure rates, but further research is necessary to clarify factors affecting neurodevelopmental outcomes.
Background & Aims: Lysosomal acid lipase deficiency (LAL-D) is an autosomal recessive condition that may present in a mild form (cholesteryl ester storage disease [CESD]), which mimics non-alcoholic fatty liver disease (NAFLD). It has been suggested that CESD may affect 1 in 40,000 and is under-diagnosed in NAFLD clinics. Therefore, we aimed to estimate the prevalence of LAL-D using analysis of genetic variation in LIPA.
View Article and Find Full Text PDFBackground & Aims: There are no approved treatments for pediatric nonalcoholic fatty liver disease (NAFLD) and there is a lack of consensus on the best outcome measure for randomized controlled trials. We performed a systematic review of treatments tested for pediatric NAFLD, the degree of heterogeneity in trial design, and endpoints analyzed in these studies.
Methods: We searched publication databases and clinical trial registries through January 7, 2018 for randomized controlled trials (published and underway) of children (<18 years) with NAFLD.