Publications by authors named "Jake Lowry"

The common marmoset (Callithrix jacchus) is increasingly recognized as an ideal nonhuman primate (NHP) at high biocontainment due to its smaller size and relative ease of handling. Here, we evaluated the susceptibility and pathogenesis of Nipah virus Bangladesh strain (NiVB) infection in marmosets at biosafety level 4. Infection via the intranasal and intratracheal route resulted in fatal disease in all 4 infected marmosets.

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Filoviruses (Family Filoviridae genera Ebolavirus and Marburgvirus) are negative-stranded RNA viruses that cause severe health effects in humans and non-human primates, including death. Except in outbreak settings, vaccines and other medical countermeasures against Ebola virus (EBOV) will require testing under the FDA Animal Rule. Multiple vaccine candidates have been evaluated using cynomolgus monkeys (CM) exposed to EBOV Kikwit strain.

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Article Synopsis
  • The study investigates how a high-fat diet (HFD) affects subcutaneous adipose tissue (scAT) and peripheral blood mononuclear cells (PBMC) over time, using rabbits as a model.
  • Results showed that HFD caused changes in the blood cells of rabbits after 5 weeks, increasing inflammation and contributing to insulin resistance by 10 weeks, but did not significantly alter the scAT's lipid metabolism or inflammation.
  • The findings suggest that targeting the inflammatory responses in PBMC could be crucial for preventing metabolic issues associated with obesity and improving health outcomes.
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Background: Although survival is historically low for patients presenting with N2 lung cancer, patients who respond to chemotherapy have up to a 30% chance for long term survival or cure. Selective pulmonary artery perfusion (SPAP) has been examined in several animal studies as a method for delivering chemotherapy in non-small cell lung cancer; however, there is a paucity of data regarding the effect of SPAP on regional lymph nodes.

Methods: Left SPAP was performed using gemcitabine on five swine and compared with standard central venous infusion in controls.

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Brucellosis, which results in fetal abortions in domestic and wildlife animal populations, is of major concern in the US and throughout much of the world. The disease, caused by Brucella abortus, poses an economic threat to agriculture-based communities. A moderately efficacious live attenuated vaccine (B.

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Current vaccines used for the prevention of brucellosis are ineffective in inducing protective immunity in animals that are chronically infected with Brucella abortus, such as elk. Using a gene discovery approach, in vivo-induced antigen technology (IVIAT) on B. abortus, we previously identified ten loci that encode products up-regulated during infection in elk and consequently may play a role in virulence.

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