Publications by authors named "Jake Coleman"
Article Synopsis
- PALB2 is a tumor suppressor that helps with DNA repair and maintaining oxidative balance in cells, particularly in the brain.
- Deleting PALB2 in mice leads to minor motor issues and worsens neurodegeneration when combined with the deletion of Atg7, a critical autophagy gene.
- The joint deletion causes increased oxidative stress and mitochondrial dysfunction, especially affecting Purkinje cells, highlighting the importance of both PALB2 and autophagy in protecting neurons from degeneration.
Background: Blood glucose level (BGL) is routinely assessed by paramedics in the out-of-hospital setting. Most commonly, BGL is measured using a blood sample of capillary origin analyzed by a hand-held, point-of-care glucometer. In some clinical circumstances, the capillary sample may be replaced by blood of venous origin.
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- - Vascular surgeons played a significant role in 225 intraoperative consultations to assist nonvascular surgical teams between January 2006 and January 2014, highlighting their importance in supporting various surgical specialties.
- - The majority of these consultations were requested by surgical oncology, orthopedics, and urology, with a focus on vascular reconstruction, hemorrhage control, and challenging dissections, predominantly in intra-abdominal procedures.
- - Patient demographics showed a prevalence of overweight males undergoing elective surgeries, with an average hospital stay of 14.7 days and a 6.2% 30-day mortality rate, showcasing the demands and outcomes related to these consultations.