Detecting novel plant pathogen threats to food system security by integrating the Plant Reactome and remote sensing.

Plant diseases constantly threaten crops and food systems, while global connectivity further increases the risks of spreading existing and exotic pathogens. Here, we first explore how an integrative approach involving plant pathway knowledgegraphs, differential gene expression data, and biochemical data informing Raman spectroscopy could be used to detect plant pathways responding to pathogen attacks. The Plant Reactome (https://plantreactome.

Efficacy of Dexamethasone in Reducing Postoperative Symptoms of the Surgical Extraction of Impacted Third Molars.

Introduction: Among anti-inflammatory medications, dexamethasone has an extended half-life and strong effects, particularly in oral surgical procedures. Administering dexamethasone helps reduce discomfort and inflammation and enhances recovery by minimizing postoperative complications. This study aimed to assess the effectiveness of dexamethasone administered before and after surgery in reducing postoperative pain and swelling and relieving mouth opening following the surgical removal of impacted third molars.

An oral non-covalent non-peptidic inhibitor of SARS-CoV-2 Mpro ameliorates viral replication and pathogenesis in vivo.

Safe, effective, and low-cost oral antiviral therapies are needed to treat those at high risk for developing severe COVID-19. To that end, we performed a high-throughput screen to identify non-peptidic, non-covalent inhibitors of the SARS-CoV-2 main protease (Mpro), an essential enzyme in viral replication. NZ-804 was developed from a screening hit through iterative rounds of structure-guided medicinal chemistry.

The Impact of Socket Shield and Implant Surface Modification With Platelet-Derived Growth Factor on Osseointegration.

Implants have become the first treatment option in the anterior esthetic region. Buccal bone loss is the sequalae of tooth extraction compromising osseointegration and cosmetic goals. The present case report is of a 47-year-old female who requested to have her fractured central incisor replaced with fixed restoration supported by an implant; the tooth had already undergone a root canal and lacked a sufficient structure for crown prosthesis placement.

An Atypical Way of Restoring an Internally Mangled Implant With the Use of a Cast Post: A Case Report.

Implant-supported prostheses can lead to biological or mechanical failures. The loosening of the abutment screw and its fracture are the most common technical complications. Recovery of fractured parts is quite challenging due to the unavailability of a universal standard screw retrieval kit on the market.

Early time wetting kinetics in surface-directed spinodal decomposition for off-critical quenches: A molecular dynamics study.

We present results from the molecular dynamics simulation of surface-directed spinodal decomposition in binary fluid mixtures (A + B) with off-critical compositions. The aim is to elucidate the role of composition ratio in the early time wetting kinetics under the influence of long-range surface potential. In our simulations, the attractive part of surface potential varies as V(z) = -ϵa/zn, with ϵa being the surface-potential strength.

Physiotherapy Rehabilitation of Scapholunate Ligament Instability Following Ganglion Cyst in a Recreational Basketball Player: A Case Report.

Ganglion cysts are prevalent benign soft tissue tumors, commonly occurring on the dorsal wrist and often associated with underlying joint structures like the scapholunate ligament (SLL), a critical stabilizer of the wrist. SLL instability, frequently resulting from acute trauma or repetitive stress, can significantly impair wrist function, causing pain, reduced range of motion, and decreased grip strength. This case report details the conservative management of a 25-year-old recreational basketball player who presented with SLL instability and a dorsal ganglion cyst following two separate wrist injuries.

Physical Therapy Perspectives for Medial Tibial Stress Syndrome in a Novice Runner: A Case Report.

Medial tibial stress syndrome (MTSS), commonly referred to as shin splints, is a prevalent overuse injury observed in runners, particularly those who are inexperienced. This condition is marked by pain along the distal anteromedial region of the tibia, often resulting from repetitive stress and insufficient adaptation of the musculoskeletal system. This case report examines the physical therapy strategies utilized in the evaluation and management of MTSS in a novice runner.

Role of Mitochondrial Dysfunctions in Neurodegenerative Disorders: Advances in Mitochondrial Biology.

Mitochondria, essential organelles responsible for cellular energy production, emerge as a key factor in the pathogenesis of neurodegenerative disorders. This review explores advancements in mitochondrial biology studies that highlight the pivotal connection between mitochondrial dysfunctions and neurological conditions such as Alzheimer's, Parkinson's, Huntington's, ischemic stroke, and vascular dementia. Mitochondrial DNA mutations, impaired dynamics, and disruptions in the ETC contribute to compromised energy production and heightened oxidative stress.

Theranostics: aptamer-assisted carbon nanotubes as MRI contrast and photothermal agent for breast cancer therapy.

Breast cancer is one of the leading causes of death among women globally, making its diagnosis and treatment challenging. The use of nanotechnology for cancer diagnosis and treatment is an emerging area of research. To address this issue, multiwalled carbon nanotubes (MWCNTs) were ligand exchanged with butyric acid (BA) to gain hydrophilic character.

The Efficacy of Ozonated Olive Oil in Crown Lengthening Procedures for Anterior Teeth: A Case Report.

Ensuring the health of the gums and supporting structures (periodontium) is crucial during dental restoration procedures to achieve optimal function and appearance of the teeth. Understanding the anatomy, the impact of restorative materials, and their interaction with the periodontium is essential for successful treatment outcomes. Crown lengthening is a surgical procedure that involves the removal of gingiva and bone tissue to expose more of the tooth structure, thereby increasing the visible portion of the tooth (clinical crown height).

Transcriptional Modulation during Photomorphogenesis in Rice Seedlings.

Light is one of the most important factors regulating plant gene expression patterns, metabolism, physiology, growth, and development. To explore how light may induce or alter transcript splicing, we conducted RNA-Seq-based transcriptome analyses by comparing the samples harvested as etiolated seedlings grown under continuous dark conditions vs. the light-treated green seedlings.

Dual-mobility implants in primary and revision total hip arthroplasty: A systematic review and meta-analysis.

Purpose: Total hip arthroplasty (THA) is a common and successful operation. However, dislocation remains a significant cause of implant failure in fixed-bearing designs. This study investigated the effect of dual-mobility implants (DM) compared to fixed-bearing (FB) implants on all-cause revisions, revisions due to dislocation, post-operative complications and functional scores in patients undergoing primary and revision THA.

Resecting Lower Segment Inferior Vena Cava Leiomyosarcoma With Middle Segment Extension While Avoiding Renal Morbidity.

Primary leiomyosarcoma of the inferior vena cava (IVC) is a rare and aggressive mesenchymal tumor, with less than 400 reported cases to date. Complete resection of the tumor with clear margins is the only proven curative treatment, providing survival benefits. Nonetheless, leiomyosarcomas in the middle segment or those extending up to it within the inferior vena cava (IVC) frequently necessitate renal reimplantation or nephrectomy, with rates varying between 56% and 75%.

Exploring the Advantages and Techniques of Intraoperative Transcholecystic Methylene Blue Injection in Laparoscopic Cholecystectomy.

Introduction With the use of advanced instruments and techniques, the reported incidence of bile duct injury is low; however, the actual frequency might be slightly higher than reported. Most surgeons might encounter bile duct injury or bile duct-related complications in their early training days. Nevertheless, with newer techniques and technologies, cases of bile duct injuries have been mostly observed in open cholecystectomy.

Author Response: Shifting Paradigms in Vascular Access: A Deep Dive into the Supraclavicular Approach's Uncharted Waters.

Jaiswal P, Chhabra PH, Saini S. Author Response: Shifting Paradigms in Vascular Access: A Deep Dive into the Supraclavicular Approach's Uncharted Waters. Indian J Crit Care Med 2024;28(6):624.

Analyzing the Relationship Between Chronic Periodontitis and Psychological Stress in Elderly Patients: A Study Protocol.

Background:  Although stress is the body's physiological response to challenging life events, chronic exposure to a stressor may not cause stress. In such cases, stress negatively impacts some physiological functions, which can lead to psychosomatic diseases. According to research, inadequate coping mechanisms and long-term stress are factors that moderate the risk and progression of periodontitis.

Effectiveness of Physiotherapy Interventions in Pleural Effusion Patients: A Comprehensive Review.

Pleural effusion, characterized by the accumulation of fluid between the parietal and visceral pleura, presents significant challenges in patient management, particularly in cases of malignant pleural effusion. Despite various therapeutic options, there is a need to evaluate the effectiveness of physiotherapy interventions specifically for pleural effusion patients, as current literature predominantly focuses on medical and surgical treatments. This comprehensive review aims to address this research gap by systematically analyzing the impact of physiotherapy on pleural effusion management, with a focus on symptom relief and improvement in quality of life.