Publications by authors named "Jaisri Jagannadham"

Wheat being the important staple food crop plays a significant role in nutritional security. A wide variety of microbial communities beneficial to plants and contributing to plant health and production are found in the rhizosphere. The wheat microbiome encompasses an extensive variety of microbial species playing a key role in sustaining the physiology of the crop, nutrient uptake, and biotic/abiotic stress resilience.

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Agricultural productivity is highly influenced by its associated microbial community. With advancements in omics technology, metagenomics is known to play a vital role in microbial world studies by unlocking the uncultured microbial populations present in the environment. Metagenomics is a diagnostic tool to target unique signature loci of plant and animal pathogens as well as beneficial microorganisms from samples.

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Article Synopsis
  • - The Pukzing cave in Mizoram, India, was studied for its bacterial diversity, resulting in the discovery of 235 bacterial isolates using various treatment methods, with the highest yield from heat treatment.
  • - The identity of these microbes was confirmed through 16S rDNA sequencing, revealing a predominance of moderate thermophiles and antimicrobial properties in 20.4% of the isolates against certain pathogens.
  • - Further genetic analysis indicated the presence of antimicrobial peptide (AMP) genes, suggesting that the unique cave microbial communities may serve as a valuable resource for future genomic research in agriculture and human health.
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Water buffalo () are an important animal resource that contributes milk, meat, leather, dairy products, and power for plowing and transport. However, mastitis, a bacterial disease affecting milk production and reproduction efficiency, is most prevalent in populations having intensive selection for higher milk yield, especially where the inbreeding level is also high. Climate change and poor hygiene management practices further complicate the issue.

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PXR is a member of nuclear receptor superfamily and a well-characterized mediator of xenobiotic metabolism. The classical mode of PXR activation involves its binding to appropriate ligand and subsequent heterodimerization with its partner RXR. However, various factors such as post-translational modifications and crosstalk with different cellular factors may also regulate the functional dynamics and behavior of PXR.

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Obesity is a global epidemic affecting over 1.5 billion people and is one of the risk factors for several diseases such as type 2 diabetes mellitus and hypertension. We have constructed a comprehensive map of the molecules reported to be implicated in obesity.

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