Publications by authors named "Jaison D Sa"
Article Synopsis
- - The study focuses on the Bcl-2 family proteins in metazoans, which play key roles in regulating apoptosis, particularly in the early evolutionary stages of these organisms, specifically analyzing four trBcl-2 homologs in a primitive metazoan.
- - Among these homologs, trBcl-2L1 and trBcl-2L2 are found to be antiapoptotic, while trBcl-2L3 and trBcl-2L4 are proapoptotic, with trBax and trBak having specific roles in permeabilizing mitochondrial membranes and regulating antiapoptotic activities.
- - The findings also reveal that the structure of trBcl-2L2
Apoptosis is regulated by evolutionarily conserved signaling pathways to remove damaged, diseased or unwanted cells. Proteins homologous to the B-cell lymphoma 2 (Bcl-2) family of proteins, the primary arbiters of mitochondrially mediated apoptosis, are encoded by the cnidarian Hydra vulgaris. We mapped interactions between pro-survival and pro-apoptotic Bcl-2 proteins of H.
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