Publications by authors named "Jair Santiago Garcia-Sotelo"
Article Synopsis
- RegulonDB is a detailed online resource launched 20 years ago that tracks transcription regulation in E. coli K-12, using historical molecular biology and recent genomic data.
- It curates research literature and includes data from ChIP and gSELEX experiments, estimating that only 10% to 30% of the gene regulatory interactions in E. coli are currently known.
- The platform features a JBrowse for visualizing datasets, a Microbial Conditions Ontology for experiment reproducibility, and analyzes Genetic Sensory-Response Units for transcription factors, enhancing its biocuration with natural language processing techniques.
RegulonDB contains the largest and currently best-known data set on transcriptional regulation in a single free-living organism, that of Escherichia coli K-12 (Gama-Castro et al. Nucleic Acids Res 36:D120-D124, 2008). This organized knowledge has been the gold standard for the implementation of bioinformatic predictive methods on gene regulation in bacteria (Collado-Vides et al.
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