Publications by Jaine L S Soares

Publications by authors named "Jaine L S Soares"

Page 1 of 1

Combining Host Genetics and Functional Analysis to Depict Inflammasome Contribution in Tuberculosis Susceptibility and Outcome in Endemic Areas.

Dhêmerson Souza De Lima Caio C B Bomfim Vinícius N C Leal Edione C Reis Jaíne L S Soares

Front Immunol

May 2021

Article Synopsis

* A specific genetic variant, rs10754558, protects against TB by enhancing the immune response through the NLRP3 inflammasome, which plays a crucial role in how the body reacts to different strains of Mtb.
* The study reveals that loss-of-function variants are linked to extra-pulmonary TB, and the activation levels of the inflammasome can differentiate between TB patients and healthy individuals in endemic areas, highlighting genetic and immune responses in TB susceptibility.

View Article and Find Full Text PDF

Gain-of-function variants in NLRP1 protect against the development of diabetic kidney disease: NLRP1 inflammasome role in metabolic stress sensing?

Jaine L S Soares Fernanda Pereira Fernandes Thiago Andrade Patente Maria B Monteiro Maria C Parisi

Clin Immunol

February 2018

Although inflammasome plays a well-known role in animal models of renal injury, limited studies in humans are available, and its participation in diabetic kidney disease (DKD) remains unknown. Aim of this study was to elucidate the contribution of inflammasome genetics in the development of DKD in type-1 diabetes (T1D). The association of functional variants in inflammasome genes with DKD was assessed by multivariate analysis in a retrospective and in a prospective cohort.