Bilateral primary vitreoretinal lymphoma masquerading as fungal endophthalmitis- a case report.

Purpose: To report a case of bilateral primary vitreoretinal lymphoma (PVRL) masquerading as endophthalmitis in a patient with a history of bilateral cataract surgery and COVID-19.

Observation: A 60-year-old male patient presented with diminution of vision in both the eyes. There was a history of bilateral cataract surgery done 2 months back at a gap of one week and COVID-19 infection treated with high dose systemic corticosteroids.

A rare case of Stenotrophomonas maltophilia endogenous endophthalmitis in pediatric age group.

Background: We report a unique case of Stenotrophomonas maltophilia-related pediatric endogenous endophthalmitis.

Case Presentation: A 10-year-old male presented with redness and loss of vision in his right eye for two weeks. Clinical examination and ultrasound features were suggestive of endophthalmitis, most likely endogenous due to the absence of a history of trauma or intraocular intervention.

Social connections related to health and well-being needs identified by children and adolescents affected by displacement in Lebanon: a participatory research study.

Introduction: The social connections surrounding children and adolescents support them in facing challenges and seeking help, ultimately acting as a protective factor in their mental, physical, and behavioral health outcomes across the life course. In complex contexts of political instability and dislocation, these social resources are often fractured, strained, or altogether unavailable, which restricts access to essential services and affects outcomes for these populations. This study aims to identify, characterize, and visually depict social connections related to the health and well-being needs of children and adolescents affected by displacement in Lebanon, by pilot testing the Participatory Assessment Tool for Mapping Social Connections (PATMSC).

Identification of specific microbiota members that induce beige fat biogenesis in response to dietary cues.

Activation of brown and beige fat biogenesis promotes metabolic health in rodents and humans, but typically requires cold exposure or pharmacological activation of β-adrenergic receptors, which may pose cardiovascular risks. Dietary intervention represents a clinically viable alternative strategy to induce beige cells and thus enhance metabolic health, though the underlying mechanisms remain poorly understood. In this study, we identified specific microbiota members in both mice and humans that promote browning of white adipose tissue (WAT) and ameliorate metabolic disorders in the context of a low-protein diet (LPD).

Orthopaedic Telemedicine Clinics: A Patient Satisfaction Survey of 522 Patients.

Background The COVID-19 pandemic necessitated the rapid adoption of telemedicine across medical specialties, including orthopedics. This study aimed to assess patient satisfaction with orthopedic telemedicine consultations and analyze the efficiency and limitations of this approach during the pandemic. Methods A cross-sectional survey was conducted involving 522 patients who underwent telephone consultations for orthopedic care between May 2020 and January 2021.

Mitigating and managing infection risk in adults treated with CAR T-cell therapy.

Chimeric antigen receptor T-cell therapy (CAR-T) has transformed the treatment paradigm of relapsed/refractory B-cell malignancies. Yet, this therapy is not without toxicities. While the early inflammation-mediated toxicities are now better understood, delayed hematopoietic recovery and infections result in morbidity and mortality risks that persist for months following CAR-T.

Associations between big five personality dimensions and lifetime use of cannabis.

Background And Objectives: With the rise in cannabis use over the last couple of decades and shifting social views around drug use, the characterization of potential predictors for the development of cannabis use disorder (CUD) may be of high relevance for the implementation of preventive measures toward this condition. We conducted a study with the aim of analyzing possible associations between personality traits and CUD.

Methods: Our sample consisted of 1335 inpatients admitted to The Menninger Clinic between September 2016 and December 2021.

Machine learning approach for detection of MACE events within clinical trial data.

Randomized controlled trials (RCTs) are the gold standard for clinical research but may not accurately reflect the impact of medicines in real-world settings. Supplementing RCTs with insights from real-world data (RWD) can address known limitations by including more diverse patient populations, additional types of sites-of-care, and practices more representative of the care most people receive. One current challenge in using RWD is the lack of an algorithmic approach to identifying outcomes.

Association of growth differentiation factor 9 expression with nuclear receptor and basic helix-loop-helix transcription factors in buffalo oocytes during maturation.

Growth differentiation factor 9 ( is an oocyte-specific paracrine factor involved in bidirectional communication, which plays an important role in oocyte developmental competence. In spite of its vital role in reproduction, there is insufficient information about exact transcriptional control mechanism of GDF9. Hence, present study was undertaken with the aim to study the expression of basic helix-loop-helix (bHLH) transcription factors (TFs) such as the factor in the germline alpha (FIGLA), twist-related protein 1 (TWIST1) and upstream stimulating factor 1 and 2 (USF1 and USF2), and nuclear receptor (NR) superfamily TFs like germ cell nuclear factor (GCNF) and oestrogen receptor 2 (ESR2) under three different maturation (IVM) groups [follicle-stimulating hormone (FSH), insulin-like growth factor-1 (IGF1) and oestradiol)] along with all supplementation group as positive control, to understand their role in regulation of GDF9 expression.

Isolated retinal astrocytic hamartoma masquerading as viral retinitis.

A female in her early 50s presented with a yellowish-white retinal lesion with fluffy margins along with flame-shaped haemorrhages and cystoid macular oedema in the left eye. Due to a recent history of fever, a presumptive diagnosis of viral retinitis was made. Following no response to antiviral therapy, the patient underwent a revision of the diagnosis using multimodal imaging.

Accelerated In Vitro Oxidative Degradation Testing of Ultra-High Molecular Weight Polyethylene (UHMWPE).

Nonabsorbable polymers used in biomedical applications are assumed to be permanently stable based on short-term testing, but some may be susceptible to oxidative degradation over several years of implantation. Traditional in vitro oxidative degradation screenings employ hydrogen peroxide (HO) solutions. However, the inherent instability of HO can compromise the consistency of oxidative conditions, especially over extended periods and at elevated temperatures used for accelerated testing.

Outcome of adult acute myeloid leukemia patients with extramedullary disease and treatment with venetoclax/hypomethylating agents.

We evaluated response to VEN/HMA in 46 patients with acute myeloid leukemia (AML) characterized by extramedullary disease (EMD). Median age was 65 (range, 19-81) years. Patients had a median of two EMD sites (range, 1-5) and 35 (76%) patients had concurrent bone marrow involvement.

Retrospective Analysis of Implant Survival Rates and Complications in Edentulous Patients with Different Bone Types.

Background: Dental implants are an effective treatment option for edentulism, which poses a substantial barrier to oral health. The quality of the bone at the implant site may have an impact on the outcome of implant therapy. The purpose of this retrospective investigation was to assess implant survival rates and problems in individuals who were edentulous and had varying forms of bone.

Longitudinal Study of Oral Precancerous Lesions: Transformation Rate and Predictive Markers for Malignancy.

Background: One of the main risk factors for the occurrence of oral cancer is oral precancerous lesions (OPLs). Early management and preventive efforts depend on knowing the transformation rate and detecting predictive signs of malignancy.

Methods: For 6 months, a group of 200 individuals with clinically diagnosed OPLs was followed up on in this longitudinal research.

Prevalence and Management of Early Childhood Caries in Preschoolers.

Background: " (ECC)" is a prevalent and serious oral health issue affecting preschool-aged children globally, with adverse effects on their overall health and well-being.

Objective: This center-based research designed to investigate the prevalence and management of ECC among preschoolers within a specific setting and evaluate associated factors.

Methods: A cross-sectional research design was employed, involving 300 preschoolers aged 3 to 5 years.

A case series of emphysematous pyelonephritis in COVID-positive patients.

Emphysematous pyelonephritis (EPN) is a rare infectious disease affecting the renal and perirenal tissues, wherein gas formation occurs in the renal parenchyma, perinephric tissues, or collecting systems. It can be life threatening with mortality rates upto 60%. Here, we report a case series of EPN during the COVID pandemic with COVID test-positive patients who were diagnosed based on clinical signs, symptoms, and CT scans.

Unravelling the Significance of NLRP3 and IL-β1 in Oral Squamous Cell Carcinoma and Potentially Malignant Oral Disorders: A Diagnostic and Prognostic Exploration.

Background: Nucleotide-binding domain-like receptor protein 3 (NLRP3), an inflammasome, is reported to be dysregulated or aberrantly expressed in chronic inflammation, leading to a myriad of inflammatory disorders, autoimmune diseases, and cancer. This study aimed to explore the expression and role of NLRP3 protein and the secreted cytokine IL-β1 in oral squamous cell carcinoma (OSCC) and potentially malignant oral disorders (PMOD).

Material & Methods: Tissue NLRP3 expression was quantified using sandwich ELISA in 30 cases each of OSCC, PMOD, and normal oral mucosa.

Decoding Cognitive Control and Cognitive Flexibility as Concomitants for Experiential Avoidance in Social Anxiety.

Avoidance is regarded as a central hallmark of social anxiety. Experiential avoidance is perilous for social anxiety, specifically among university students (young adults). Additionally, cognitive control and cognitive flexibility are crucial components of executive functions for a fulfilling and healthy lifestyle.

Best Practice Considerations by The American Society of Transplant and Cellular Therapy: Infection Prevention and Management After Chimeric Antigen Receptor T Cell Therapy for Hematological Malignancies.

Chimeric antigen receptor (CAR) T-cell therapy is rapidly advancing, offering promising treatments for patients with hematological malignancy. However, associated infectious complications remain a significant concern because of their contribution to patient morbidity and non-relapse mortality. Recent epidemiological insights shed light on risk factors for infections after CAR T-cell therapy.