Publications by authors named "Jaimie Anandan"
Article Synopsis
- The study investigates the role of β-hCG in breast cancer, particularly in Breast Invasive Carcinoma (BRCA), assessing its gene expression and implications for clinical outcomes.
- Data from various gene expression databases and laboratory techniques were used to analyze β-hCG levels, particularly focusing on its connection to BRCA1 mutations and immune cell presence in tumors.
- Results indicate that β-hCG is upregulated in breast cancers with BRCA1 mutations, suggesting it could serve as a potential target for treatment in BRCA1-deficient patients.
BRCA1 mutation carriers have a greater risk of developing cancers in hormone-responsive tissues like breasts and ovaries. However, this tissue-specific incidence of BRCA1 related cancers remains elusive. The majority of the BRCA1 mutated breast cancers exhibit typical histopathological features of high-grade tumors, with basal epithelial phenotype, classified as triple-negative molecular subtype and have a higher percentage of DNA damage and chromosomal abnormality.
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