Publications by authors named "Jaime Pena-Garcia"
Article Synopsis
- The study analyzes free flap reconstruction in patients with traumatic head and neck injuries, focusing on experiences from multiple institutions, involving 103 cases.
- Most injuries were due to gunshot wounds (85%) and motor vehicle accidents (11%), with the majority requiring bone reconstruction (82%).
- Free flap failures (9% of cases) occurred exclusively in gunshot wound patients and were linked to multiple injured sites, while preoperative antibiotics were found to significantly reduce certain postoperative complications.
Background: Spontaneous cerebrospinal fluid (sCSF) leaks develop from pressure erosion due to idiopathic intracranial hypertension, treatment of which is paramount to preventing recurrence. Direct measurements of intracranial pressure (ICP) for monitoring response to treatment via lumbar drain (LD) or ventriculostomy are invasive and have risks. The objectives of this study are to determine whether ultrasonographic measurements of optic nerve sheath diameter (ONSD) correlate with LD ICP in patients with sCSF leaks undergoing treatment, and whether ONSDs are larger in patients with sCSF leaks than controls.
View Article and Find Full Text PDFLateral nasal wall extension of the nasoseptal flap for skull-base and medial orbital wall defects.
Int Forum Allergy Rhinol
September 2019
Article Synopsis
- - The study introduces a new method for using the nasoseptal flap (NSF) to repair both skull-base and medial orbital wall defects during endoscopic surgery, improving reconstruction techniques for sinonasal and skull-base tumors.
- - Three elderly patients underwent the procedure successfully, with all defects effectively covered and minimal postoperative eyelid swelling reported.
- - Results indicate that this modified NSF technique provides reliable closure of large defects while ensuring good cosmetic outcomes after surgery, with patients showing no cerebrospinal fluid leaks during follow-up.
Background: Mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene result in defective Cl transport and cause chronic bacterial infections in the upper and lower airways of cystic fibrosis (CF) patients. Ivacaftor is a CFTR potentiator that improves Cl transport in CF patients with at least 1 copy of the G551D mutation. Resveratrol is also a potent CFTR potentiator that increases determinants of mucociliary transport.
View Article and Find Full Text PDFBackground: Biofilms may contribute to refractory chronic rhinosinusitis (CRS), as they lead to antibiotic resistance and failure of effective clinical treatment. l-Methionine is an amino acid with reported biofilm-inhibiting properties. Ivacaftor is a cystic fibrosis transmembrane conductance regulator (CFTR) potentiator with mild antimicrobial activity via inhibition of bacterial DNA gyrase and topoisomerase IV.
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