Modulation of Gut Microbiota Composition and Microbial Phenolic Catabolism of Phenolic Compounds from L. and L.

The impact of the nonbioaccessible fraction of two phenolic-rich extracts from L. (yarrow) and L. (marjoram) on the modulation of the human gut microbiota was investigated .

In Vitro Antioxidant, Anti-Inflammatory Activity and Bioaccessibility of Ethanolic Extracts from Mexican Leaf.

This study aimed to assess the antioxidant and anti-inflammatory properties, and bioaccessibility of ethanolic extracts using pressurized liquid extraction with varying ethanol concentrations (0%, 30%, 50%, 70%, and 100%) in water-ethanol mixtures. Quercetin derivatives and neochlorogenic acid were identified as major compounds via high-performance liquid chromatography with diode array detection. The 70% ethanol extract displayed the highest antioxidant activity and phenolic content, highlighting a strong correlation between phenolics and antioxidant potential.

Novel bioactive extract from yarrow obtained by the supercritical antisolvent-assisted technique inhibits lipid metabolism in colorectal cancer.

Altered lipid metabolism in cancer is associated to dissemination and prognosis. Bioactive compounds naturally occurring in L. (yarrow) have been reported to exert antitumour activities.

Correction: Villalva et al. Antioxidant, Anti-Inflammatory, and Antibacterial Properties of an L. Extract and Its Fractions Obtained by Supercritical Anti-Solvent Fractionation against . 2022, , 1849.

Table S1 in the Supplementary Material (Phenolic compounds identified in yarrow samples by using HPLC-ESI-QTOF-MS) in the original paper [...

Combination of Fenugreek and Quinoa Husk as Sources of Steroidal and Triterpenoid Saponins: Bioactivity of Their Co-Extracts and Hydrolysates.

Saponins, both steroidal and triterpenoid, exhibit distinct bioactivities. However, they are not commonly found together in natural sources; instead, sources tend to be rich in one type or another and mainly in the form of saponins rather than the sapogenin aglycones. Developing co-extracts containing both saponin or sapogenin types would be a strategy to harness their respective bioactivities, yielding multibioactive extracts.

Development of Pectin Particles as a Colon-Targeted Marjoram Phenolic Compound Delivery System.

Marjoram is a culinary herb that has been widely employed in folk medicine and presents a high content in phenolics. Thus, the aim of this project was to design formulations to encapsulate phenolic compounds from marjoram to allow their release in the colon. For this purpose, pectin was used as an encapsulating agent, applying two different encapsulation techniques (ionic gelation and spray-drying), followed by a CaCl bath.

Theoretical framework to evaluate antioxidant synergistic effects from the coextraction of marjoram, rosemary and parsley.

Synergies between compounds in food ingredients have been commonly obtained by the mixing of extracts produced individually. A different approach, based on the coextraction of plants and a new theoretical framework to identify synergistic and antagonistic effects in the coextracts, has been proposed in this study for the first time. The Pressurized Liquid Extraction (PLE) of rosemary and marjoram with parsley at several plant ratios was carried out and the antioxidant activity (ABTS and cellular assays) and phenolic compounds of the extracts were evaluated.

Polyphenols as NLRP3 inflammasome modulators in cardiometabolic diseases: a review of studies.

The nucleotide-binding domain and leucine-rich repeat containing receptors (NLRs) are components of the innate immune system, important in coordinating the inflammatory response. Among them, NLRP3 can form inflammasomes, multiprotein complexes activating the inflammatory caspase-1 and leading, through a cell death-mediated signaling cascade, to the release of several proinflammatory cytokines. Dietary polyphenols, plant secondary metabolites, have been reported to exhibit anti-inflammatory properties, although studies have focused most on their effect on the expression of the final circulating cytokines rather than on the upstream signals activating the NLRP3 inflammasome.

Reply to Frański, R.; Beszterda-Buszczak, M. Comment on "Villalva et al. Antioxidant, Anti-Inflammatory, and Antibacterial Properties of an L. Extract and Its Fractions Obtained by Supercritical Anti-Solvent Fractionation against . 2022, , 1849".

Franski and Beszterda-Buszczak [...

Biological Activities of Miracle Berry Supercritical Extracts as Metabolic Regulators in Chronic Diseases.

() is a berry fruit from West Africa with the ability to convert the sour taste into a sweet taste, and for this reason, the fruit is also known as the "miracle berry" (MB). The red and bright berry is rich in terpenoids. The fruit's pulp and skin contain mainly phenolic compounds and flavonoids, which correlate with their antioxidant activity.

Implication of the Polymeric Phenolic Fraction and Matrix Effect on the Antioxidant Activity, Bioaccessibility, and Bioavailability of Grape Stem Extracts.

The bioaccessibility and bioavailability of phenolics compounds of two grape stem extracts with different composition were studied. High polymeric extract (HPE) presented a higher content of total phenolics (TPC), procyanidins, hemicelluloses, proteins, and ashes, whereas low procyanidin extract (LPE) showed a higher fat, soluble sugars, and individual phenolic compounds content. Corresponding to its higher total phenolics content, HPE possesses a higher antioxidant activity (TEAC value).

Bioavailability Assessment of Yarrow Phenolic Compounds Using an In Vitro Digestion/Caco-2 Cell Model: Anti-Inflammatory Activity of Basolateral Fraction.

In this study, a combined in vitro digestion/Caco-2 model was performed with the aim to determine the phenolic compounds bioavailability of two yarrow extracts. HPLC-PAD characterisation indicated that the main components in both extracts were 3,5-dicaffeoylquinic acid (DCQA) and luteolin-7--glucoside. Analyses after the simulated digestion process revealed that phenolic composition was not affected during the oral phase, whereas gastric and intestinal phases represented critical steps for some individual phenolics, especially intestinal step.

Encapsulation of Marjoram Phenolic Compounds Using Chitosan to Improve Its Colon Delivery.

In this study, chitosan particles were used to encapsulate marjoram phenolic compounds as colon-specific drug-delivery systems. The microparticles were prepared by ionic gelation and spray-drying techniques and varying amounts of polymer and extract, along with different method conditions. The spray drying of microparticles (0.

Antioxidant, Anti-Inflammatory, and Antibacterial Properties of an L. Extract and Its Fractions Obtained by Supercritical Anti-Solvent Fractionation against .

The main objective of this work is to evaluate the potential utility of an extract (yarrow extract, YE) in the control of infection. The supercritical anti-solvent fractionation (SAF) process of YE allowed the obtaining of two different fractions: yarrow's precipitated fraction (YPF), enriched in most polar phenolic compounds (luteolin-7--glucoside, luteolin, and 3,5-dicaffeoylquinic acid), and yarrow's separator fraction (YSF), enriched in monoterpenes and sesquiterpenes, mainly containing camphor, artemisia ketone, and borneol. YE was effective in reducing reactive oxygen species (ROS) production in human gastric AGS cells by 16% to 29%, depending on the strain.

Modelling the dynamics of Pinus sylvestris forests after a die-off event under climate change scenarios.

In recent decades, die-off events in Pinus sylvestris populations have increased. The causes of these phenomena, which are usually related to local and regional extreme hot droughts, have been extensively investigated from a physiological viewpoint. However, the consequences of die-off process in terms of demography and vegetation dynamics have been less thoroughly addressed.

Molecular Characterization of Four Mexican Isolates of Trypanosoma cruzi and Their Profile Susceptibility to Nifurtimox.

Purpose: The objective of this study was to molecularly characterize Mexican isolates of T. cruzi obtained from infected triatomine bugs (the vectors of T. cruzi) and to evaluate their susceptibility to Nifurtimox (NFX).

Climatic and stand drivers of forest resistance to recent bark beetle disturbance in European coniferous forests.

Bark beetle infestation is a major driver of tree mortality that may be critical for forest persistence under climate change and the forecasted increase of extreme heat and drought episodes. Under this context, the environmental position of host tree populations within the species' climatic niche (central vs. marginal populations) is expected to be a determinant in the dynamics of insect-host systems.

Short-term forest resilience after drought-induced die-off in Southwestern European forests.

Drought-induced die-off in forests is becoming a widespread phenomenon across biomes, but the factors determining potential shifts in taxonomic and structural characteristics following mortality are largely unknown. We report on short-term patterns of resilience after drought-induced episodes of tree mortality across 48 monospecific forests from Morocco to Slovenia. Field surveys recorded plants growing beneath a canopy of dead, defoliated and healthy trees.

Sustainable Extraction Techniques for Obtaining Antioxidant and Anti-Inflammatory Compounds from the Lamiaceae and Asteraceae Species.

L. and L., within Lamiaceae family, and L.

Marjoram extract prevents ischemia reperfusion-induced myocardial damage and exerts anti-contractile effects in aorta segments of male wistar rats.

Ethnopharmacological Relevance: Marjoram (Origanum majorana L.) is an herb traditionally used as a medicine in different countries, as Morocco and Iran, because of its beneficial cardiovascular effects. Some studies suggest that these effects are due, at least in part, to the presence of phenolic compounds such as rosmarinic acid (RA) and luteolin.

Species climatic niche explains post-fire regeneration of Aleppo pine (Pinus halepensis Mill.) under compounded effects of fire and drought in east Spain.

Fire and drought are two major agents that shape Mediterranean ecosystems, but their interacting effects on forest resilience have not been yet fully addressed. We used Pinus halepensis to investigate how compound fire-drought regimes determine the success of post-fire regeneration. We measured the density of P.

Information and Communication Technologies for Managing Frailty: A Systematic Literature Review.

Frailty is a prevalent condition among Canadians; over one million are diagnosed as medically frail, and in the next ten years this number will double. Information and telecommunication technologies can provide a low-cost method for managing frailty more proactively. This study aims to examine the range and extent of information and telecommunication technologies for managing frailty in older adults, their technology readiness level, the evidence, and the associated outcomes.

Nd:YAG membranotomy for sub-inner limiting membrane hemorrhage: a case report.

A 16-year-old male patient presented with a 12-days sudden painless loss of vision in his left eye after diving in a lake. Best corrected visual acuity (BCVA) in the left eye was counting fingers. Anterior segment was unremarkable.

The Health Benefits of the Bioactive Compounds in Foods.

The health benefits of consuming certain foods have been commonly known since ancient times [...

Valorisation of Grape Stems as a Source of Phenolic Antioxidants by Using a Sustainable Extraction Methodology.

Pressurized liquid extraction with ethanol:water mixtures was proposed for obtaining phenolic antioxidants from grape stems. The optimal extraction conditions were elucidated by using a central composite rotatable design (solvent (X, 0-100% ethanol:water /), temperature (X, 40-120 °C) and time (X, 1-11 min)). Response surface methodology determined 30% ethanol:water, 120 °C and 10 min as the optimal extraction conditions regarding total phenolic content (TPC) (185.