Attention-deficit/hyperactivity disorder in children and adolescents: An event-related potential study of working memory.

Working memory (WM) impairments have been frequently observed as an important feature of attention-deficit/hyperactivity disorder (ADHD). Event-related potential (ERP) differences between ADHD and healthy controls (HC) would be expected during WM task performance. Especially, the so-called slow wave (SW), which is related to the retention process, might present amplitude differences in ADHD.

Neurophysiological differences between ADHD and control children and adolescents during the recognition phase of a working memory task.

Impairment of executive functions including attention and working memory (WM) have been proposed as an important feature of Attention Deficit and Hyperactivity Disorder (ADHD). During the recognition phase of a delayed match-to-sample test (DMTS) a reduced N2pc component, related to the attentional selection of the memorized item and a reduced distractor positivity (Pd), related to the processing suppression of distractors are expected in ADHD subjects. For the purpose of the study, twenty-nine ADHD subjects diagnosed with a structured interview and the DuPaul questionnaire, were included in the study.

Frequency coupling of low and high frequencies in the EEG of ADHD children and adolescents in closed and open eyes conditions.

The present report examines the possible differences in absolute Power Spectral Density (PSD), the topography of brain rhythms, and low frequency (delta and theta) vs. beta PSD when attention deficit disorder (ADHD) children and controls are compared. These results would potentially be useful to test the validity of the developmental lag and differential developmental models for ADHD.

MULTI-CRITERIA DECISION ANALYSIS AS A DECISION-SUPPORT TOOL FOR DRUG EVALUATION: A PILOT STUDY IN A PHARMACY AND THERAPEUTICS COMMITTEE SETTING.

Objectives: The aim of this study was to develop and to assess a specific Multi-Criteria Decision Analysis (MCDA) framework to evaluate new drugs in an hospital pharmacy and therapeutics committee (P&TC) setting.

Methods: A pilot criteria framework was developed based on the EVIDEM (Evidence and Value: Impact on DEcisionMaking) framework, together with other relevant criteria, and assessed by a group of P&TC's members. The weighting of included criteria was done using a 5-point weighting technique.

The neurophysiology of working memory development: from childhood to adolescence and young adulthood.

Working memory (WM) is an important cognitive function that is necessary to perform our daily activities. The present review briefly describes the most accepted models underlying WM and the neural networks involved in its processing. The review focuses on how the neurophysiological mechanisms develop with age in the periods from childhood to adolescence and young adulthood.

Event related potentials changes associated with the processing of auditory valid and invalid targets as a function of previous trial validity in a Posner's paradigm.

The present study tries to analyze the neural basis of the so-called "Inter-trial Validity-Invalidity Effects" by means of Event-Related Potentials. The N1, P2, P3a and P3b components were examined. The aim is to show the sequential effects on Event-Related Potentials by analyzing the effect of previous trial condition (n-1) in the processing of current trial target (n).