Publications by authors named "Jaime Diegoperez-Ramirez"
An increased number of dengue cases with neurological complications have been reported in recent years. The lack of reliable animal models for dengue has hindered studies on dengue virus (DENV) pathogenesis and cellular tropism in vivo. We further investigate the tropism of DENV for the human central nervous system (CNS), characterizing DENV interactions with cell surface proteins in human CNS cells by virus overlay protein binding assays (VOPBA) and coimmunoprecipitations.
View Article and Find Full Text PDFUnlabelled: Pediatric astrocytomas, a leading cause of death associated with cancer, are the most common primary central nervous system tumors found in children. Most studies of these tumors focus on adults, not on children. We examined the global protein and microRNA expression pattern by 2D SDS-PAGE, mass spectrometry (MALDI-TOF), and RT(2) miRNA PCR Array System.
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- The study investigates how the expression of the Ki67 protein affects survival rates among pediatric patients with malignant gliomas, particularly anaplastic astrocytoma and glioblastoma multiforme.
- The research analyzed 21 patients, finding that 12 had elevated Ki67 levels; however, this overexpression did not significantly correlate with survival outcomes, although it did link to more aggressive tumor types.
- A critical finding is that being younger than 11 years old indicates a poorer prognosis for these patients, with an overall survival rate of 49% after 10 years.
Background: Clinical, histological, and more recently, molecular factors have been described as important in survival of the patient with medulloblastoma. Best survival results include aggressive chemotherapeutic protocols. More exact risk analysis may differentiate patients who require aggressive treatments from those with low risk who may respond adequately to less aggressive protocols.
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