The role of different hyaluronic acids in the articular cartilage of rabbit.

Purpose: To elucidate if the differences found in the physico-chemical and rheological behaviour of Hyaluronic Acids result in different in vivo activity. For this purpose two Hyaluronic Acids (HA), HA-1 and HA-2, with similar molecular weight but different percentage of concentration variation, were compared through an osteoarthritis model.

Methods And Materials: Osteoarthritis was induced in white New Zealand rabbits by anterior cruciate ligament section.