Publications by authors named "Jaime Andres Garcia-Diosa"

Article Synopsis
  • DNA origami nanostructures (DONs) effectively scavenge reactive oxygen species (ROS), particularly outperforming double-stranded (ds) DNA in quenching singlet oxygen by a significant margin.
  • In experimental conditions, DONs showed a scavenging efficiency approximately 50,000 times greater than that of dsDNA, particularly protecting E. coli cells from oxidative damage caused by ROS.
  • This remarkable efficiency is due to the unique structural properties of DONs, allowing for a higher concentration of reactive guanine bases, which react specifically with singlet oxygen, highlighting their potential in therapeutic applications against oxidative stress.
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DNA origami nanostructures are a powerful tool in biomedicine and can be used to combat drug-resistant bacterial infections. However, the effect of unmodified DNA origami nanostructures on bacteria is yet to be elucidated. With the aim to obtain a better understanding of this phenomenon, the effect of three DNA origami shapes, i.

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Photodynamic therapy (PDT) using TiO nanoparticles has become an important alternative treatment for different types of cancer due to their high photocatalytic activity and high absorption of UV-A light. To potentiate this treatment, we have coated commercial glass plates with TiO nanoparticles prepared by the sol-gel method (TiO -m), which exhibit a remarkable selectivity for the irreversible trapping of cancer cells. The physicochemical properties of the deposited TiO -m nanoparticle coatings have been characterized by a number of complementary surface-analytical techniques and their interaction with leukemia and healthy blood cells were investigated.

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