Publications by authors named "Jaime A Gonzalez-Hernandez"
Article Synopsis
- Microorganisms associated with humans can influence our physiology in various ways, but the specific molecular interactions behind these effects are not well understood.
- Researchers developed a new technology called BASEHIT to explore the interactions between over 500 bacterial strains and thousands of human proteins, uncovering a vast network of host-microbiota interactions.
- The findings suggest that these interactions may play important roles in areas like immune response, tissue remodeling, and niche colonization, highlighting the complex relationship between human health and our microbiome.
Article Synopsis
- The human body hosts numerous metabolites from various sources such as cells, diet, and microbes, many of which influence G-protein-coupled receptors (GPCRs), vital for cell signaling.
- A new technology called PRESTO-Salsa allows researchers to test over 300 GPCRs simultaneously in a single well, enabling the screening of 1,041 metabolites for novel interactions.
- The study utilized PRESTO-Salsa to map microbiome-GPCR interactions, revealing unique patterns of receptor engagement and identifying a specific microbial protease that activates a certain receptor, highlighting the complexity of metabolite-GPCR relationships.
Microbiota-derived metabolites that elicit DNA damage can contribute to colorectal cancer (CRC). However, the full spectrum of genotoxic chemicals produced by indigenous gut microbes remains to be defined. We established a pipeline to systematically evaluate the genotoxicity of an extensive collection of gut commensals from inflammatory bowel disease patients.
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- Researchers developed a new technique called rapid extracellular antigen profiling (REAP) to efficiently find autoantibodies that target extracellular proteins in the body, which are important for understanding autoimmune diseases.
- The REAP method was tested on samples from patients with autoimmune polyglandular syndrome type 1, successfully identifying known and new autoantibodies linked to the disease.
- Further testing with patients suffering from systemic lupus erythematosus revealed various autoantibodies correlated with disease severity and specific symptoms, showcasing REAP's potential to enhance understanding of autoimmune conditions and patient health.