Publications by authors named "Jaila Dias Borges Lalwani"
The aim of the present study was to assess functional performance and perceived fatigue post-COVID-19 in asymptomatic or mildly symptomatic patients. A cross-sectional prospective study was conducted of 1448 individuals who were evaluated for perceived fatigue, functional capacity, handgrip strength, physical activity level, pain and dyspnea. IgG anti-SARS-CoV-2 nucleocapsid serology results and self-declared symptoms were used to classify patients into three study groups: SARS-CoV-2 seronegative, asymptomatic SARS-CoV-2 seropositive and mild infection SARS-CoV-2 seropositive.
View Article and Find Full Text PDFHybrid Immunity Results in Enhanced and More Sustained Antibody Responses after the Second Sinovac-CoronaVac Dose in a Brazilian Cohort: DETECTCoV-19 Cohort.
Viruses
September 2023
We measured anti-SARS-CoV-2 antibody responses before and after CoronaVac (inactivated) vaccination in a case-control study performed in CoronaVac-immunized individuals participating in a longitudinal prospective study of adults in Manaus (DETECTCoV-19). Antibody responses were measured by standard serological immunoassays. Peak anti-S-RBD and neutralizing RBD-ACE2 blocking antibody responses after two doses of CoronaVac vaccine were similar in vaccine breakthrough cases ( = 9) and matched controls ( = 45).
View Article and Find Full Text PDFArticle Synopsis
- A study analyzed the immune response (specifically IgA and IgG antibodies) in COVID-19 patients, focusing on the spike and nucleocapsid proteins of the virus to relate it to disease severity.
- The research found that hospitalized patients with severe symptoms had a significantly stronger IgG response compared to those with mild symptoms, indicating a correlation between antibody levels and disease outcome.
- The findings suggest that tracking specific antibody responses could help in understanding disease progression and potentially improving patient outcomes.
Antibody cross-reactivity and evidence of susceptibility to emerging Flaviviruses in the dengue-endemic Brazilian Amazon.
Int J Infect Dis
April 2023
Objectives: Several Flaviviruses can co-circulate. Pre-existing immunity to one virus can modulate the response to a heterologous virus; however, the serological cross-reaction between these emerging viruses in dengue virus (DENV)-endemic regions are poorly understood.
Methods: A cross-sectional study was performed among the residents of Manaus city in the state of Amazonas, Brazil.
An Electrochemical Immunosensor Based on Carboxylated Graphene/SPCE for IgG-SARS-CoV-2 Nucleocapsid Determination.
Biosensors (Basel)
December 2022
The COVID-19 pandemic has emphasized the importance and urgent need for rapid and accurate diagnostic tests for detecting and screening this infection. Our proposal was to develop a biosensor based on an ELISA immunoassay for monitoring antibodies against SARS-CoV-2 in human serum samples. The nucleocapsid protein (N protein) from SARS-CoV-2 was employed as a specific receptor for the detection of SARS-CoV-2 nucleocapsid immunoglobulin G.
View Article and Find Full Text PDFHigh anti-SARS-CoV-2 antibody seroconversion rates before the second wave in Manaus, Brazil, and the protective effect of social behaviour measures: results from the prospective DETECTCoV-19 cohort.
Lancet Glob Health
November 2021
Article Synopsis
- The study examines anti-SARS-CoV-2 nucleocapsid IgG antibody seroconversion rates among adult residents of Manaus, Brazil, amid the COVID-19 pandemic, specifically focusing on data before the second wave of cases.
- A convenience sample was taken from the DETECTCoV-19 study cohort, involving participants with two serum sample collections and strict eligibility criteria regarding prior COVID-19 diagnoses.
- Results indicated that out of 2,496 participants returning for follow-up, 559 were initially seropositive, and analyses were conducted to determine correlations between seroconversion and various sociodemographic and health-related factors.
SARS-CoV-2 seroprevalence and associated factors in Manaus, Brazil: baseline results from the DETECTCoV-19 cohort study.
Int J Infect Dis
September 2021
Background: Manaus, located in the Brazilian rainforest, has experienced two health system collapses due to the coronavirus disease 2019 (COVID-19) pandemic. However, little is known about which groups among the general population have been most affected.
Methods: A convenience sampling strategy via online advertising recruited 3046 adults between 19 August 2020 and 2 October 2020.
Introduction: Human T-lymphotropic virus type 1 and 2 (HTLV-1/2) is endemic in Brazil, but few studies have investigated the seroprevalence of HTLV and its subtypes among blood donors in the capital city Manaus, Amazonas State, Brazil.
Aim: To estimate the seroprevalence of HTLV-1/2 and to identify circulating subtypes among blood donors in Manaus.
Materials And Methods: Blood donors (2001-2003) were screened for HTLV-1/2 antibodies by ELISA.