Publications by authors named "Jaikitry Rawal"
Introduction: Acute skeletal muscle wasting is a major contributor to post critical illness physical impairment. However, the bone response remains uncharacterized. We prospectively investigated the early changes in bone mineral density (BMD) and fracture risk in critical illness.
View Article and Find Full Text PDFObjectives: A rapid and early loss of skeletal muscle mass underlies the physical disability common amongst survivors of critical illness. However, skeletal muscle function depends not only on its quantity but its quality, which may be adversely affected. We set out to characterise the changes in macroscopic muscle echogenicity and fascial characteristics that occur early in critical illness, and to relate these to microscopic histologically defined myofibre necrosis and fascial pathology.
View Article and Find Full Text PDFArticle Synopsis
- Survivors of critical illness often experience significant skeletal muscle wasting that impacts their overall function, which is the focus of this study.
- The study involved 63 critically ill patients from two hospitals in England, with data collected on muscle loss through serial ultrasounds and multiple other measurement techniques within the first ten days of ICU admission.
- Results showed a notable reduction in muscle size, particularly in patients with multiorgan failure, highlighting the importance of understanding protein synthesis and breakdown in managing critical illness recovery.