Publications by authors named "Jaideep Kanungo"
Article Synopsis
- The study investigates the potential link between different types of central venous access (UVC vs. PICC) in preterm infants and the risk of developing necrotizing enterocolitis (NEC).
- Researchers used data from the Canadian Neonatal Network to compare three groups of preterm infants based on their initial vascular access methods: those with PICC, UVC, and UVC followed by PICC, totaling 497 infants.
- The findings showed no significant association between the type of central venous access and NEC, but the authors suggest that more comprehensive prospective studies are necessary to further assess this relationship.
Background And Objectives: Nasal intermittent positive pressure ventilation (NIPPV) has been shown to be superior to nasal continuous positive airway pressure (CPAP) postextubation in preterm neonates. However, studies have not permitted high CPAP pressures or rescue with other modes. We hypothesized that if CPAP pressures >8 cmH2O and rescue with other modes were permitted, CPAP would be noninferior to NIPPV.
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- The study aimed to evaluate the impact of inhaled nitric oxide (iNO) treatment on the neurodevelopmental outcomes of preterm neonates (born before 29 weeks) suffering from hypoxaemic respiratory failure.
- Researchers analyzed data from neonates born between 2010 and 2018, comparing those who received iNO in their first week of life with those who did not, focusing on outcomes measured at 18-24 months corrected age.
- The findings revealed that although the iNO group had more severe health issues and higher rates of complications, there was no significant difference in the likelihood of neurodevelopmental impairment among surviving infants treated with iNO compared to those not treated.
Objective: We examine the effect of birth weight (BW) for gestational age (GA) on the temperatures reached during the treatment of neonatal hypoxic-ischemic encephalopathy (HIE) with therapeutic hypothermia (TH).
Study Design: Retrospective data of 1,736 neonates with HIE who received TH were extracted from the Canadian Neonatal Network database for neonates admitted from 2010 to 2017. Neonates were stratified into three BW groups: small for GA < 10th centile, large for GA > 90th centile, and according to GA 10th to 89th centile at a given gestation using Canadian population data norms.
Article Synopsis
- Patent ductus arteriosus (PDA) is a common heart condition in preterm infants, and there's uncertainty about the best treatment, with practices varying across Canadian neonatal intensive care units (NICUs).
- This study aims to compare the effectiveness of different medications—indomethacin, ibuprofen, and acetaminophen—in treating PDA in extremely preterm infants (born before 29 weeks gestation).
- The main goal is to assess the failure rate of these treatments, looking at the need for additional medical or surgical intervention, along with other related clinical outcomes.
Objective: To evaluate the association of a combined exposure to antenatal steroids and prophylactic indomethacin with the outcome of spontaneous intestinal perforation (SIP) among neonates born at <26 weeks of gestation or <750 g birth weight.
Study Design: We conducted a retrospective study of preterm infants admitted to Canadian Neonatal Network units between 2010 and 2018. Infants were classified into 2 groups based on receipt of antenatal steroids; the latter subgrouped as recent (≤7 days before birth) or latent (>7 days before birth) exposures.
Objective: To determine if the reported reduction in hospital-acquired infections is due to reduced central line-associated blood stream infections (CLABSI) or non-CLABSIs.
Study Design: A retrospective cohort study design was used to describe the change in organism pattern and incidence of hospital-acquired infections (CLABSIs and non-CLABSIs) in neonates <33 weeks of gestation admitted to tertiary neonatal intensive care units in the Canadian Neonatal Network between January 1, 2010, and December 31, 2016. Hospital-acquired infection was diagnosed when a pathogenic organism was isolated from blood or cerebrospinal fluid in a neonate with suspected sepsis.
Objective: To estimate the effect of maternal age on survival free of major morbidity among preterm newborns younger than 33 weeks of gestation at birth.
Methods: Data from a retrospective cohort of preterm newborns younger than 33 weeks of gestation admitted to Canadian neonatal intensive care units between 2003 and 2008 were analyzed. The primary outcome was survival without major morbidity (defined as bronchopulmonary dysplasia, intraventricular hemorrhage grade 3 or 4, periventricular leukomalacia, retinopathy of prematurity stage 3, 4 or 5, or necrotizing enterocolitis stage 2 or 3).