Safety assessment of a novel, dietary pyrroloquinoline quinone disodium salt (mnemoPQQ).

Pyrroloquinoline quinone (PQQ), a potent coenzyme antioxidant naturally occurring in foods, has been demonstrated to protect brain cells by enhancing the expression of nerve growth factors (NGF) and NGF receptors, and suppressing the fibril formation and aggression of amyloid β. We developed mnemoPQQ, a novel PQQ disodium salt and assessed its safety in GLP compliant toxicity studies. Acute toxicity studies of mnemoPQQ in Wistar rats revealed that its LD was 1825- and 1410 mg/kg body weight (bw) in male and female rats, respectively, whereas its acute dermal LD was >2000 mg/kg bw.