Circulating miR-146a-5p and miR-132-3p as potential diagnostic biomarkers in epilepsy.

Objective: MiRNAs are important gene-regulating agents in epilepsy development, according to new research. The purpose of this study is to investigate the relationship between serum expression of miR-146a-5p and miR-132-3p and epilepsy in Egyptian patients as potential diagnostic and therapeutic biomarkers.

Methods: MiR-146a-5p and miR-132-3p were measured in the serum of 40 adult epilepsy patients and 40 controls using real-time polymerase chain reaction.

Assessment of the cognitive function in adult Egyptian patients with obstructive sleep apnea using the Montreal Cognitive Assessment: a retrospective large-scale study.

Study Objectives: Sleep apnea is a chronic disorder associated with multiple recognized comorbidities. Only a few studies focus on evaluating the cognitive profile in patients diagnosed with sleep apnea. The aim of the study was to assess the cognitive functions in this population using the Montreal Cognitive Assessment.

Rapid eye movement (REM) sleep and seizure control in idiopathic generalized epilepsy.

Background: Sleep and epilepsy are bedfellows, and they affect each other reciprocally. Despite the well-known relationship between sleep and epilepsy, data about the impact of sleep on seizure control and responsiveness to therapy are scarce.

Objective: The aim of this work was to study the impact of sleep architecture in drug-naïve patients with idiopathic generalized epilepsy (IGE) on seizure control and responsiveness to treatment.

Correlation of levetiracetam concentration in peripheral blood mononuclear cells with clinical efficacy: A sensitive monitoring biomarker in patients with epilepsy.

Purpose: Therapeutic drug monitoring (TDM) is increasingly recommended in antiepileptic drug (AED) therapy, yet a complex relationship exists between the unbound-drug serum concentration (C) as a monitoring biomarker and clinical efficacy. The study was designed to investigate the validity of the intracellular unbound-drug concentration in Peripheral Blood Mononuclear Cells (C) as a feasible TDM tool in relation to levetiracetam (LEV).

Methods: Patients from epilepsy out-patient centre were included in a 4-month descriptive prospective study.

Sleep architecture in patients with Juvenile Myoclonic Epilepsy.

Aim: The aim is to analyze the sleep architecture using polysomnography (PSG) in patients with Juvenile Myoclonic Epilepsy (JME): (newly diagnosed and those on valproate drug) attending epilepsy clinic at Alexandria University Hospitals.

Methods: This study involved 20 patients with JME on valproate (age: 22.40 ± 5.